• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Understanding of MLL-related leukemogenesis and identification of new therapeutic targets

Research Project

Project/Area Number 15K19601
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Aoki Yuki  東京医科歯科大学, 医学部附属病院, 非常勤講師 (90706839)

Research Collaborator TAKAGI Masatoshi  東京医科歯科大学, 茨城県小児・周産期地域医療学講座, 准教授 (10406267)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsNSGマウス / 異種移植 / MLL / ALL / DNA修復機構 / NSGマウス / 乳児白血病 / 疾患モデル / 白血病幹細胞
Outline of Final Research Achievements

MLL-rearranged infantile acute lymphocytic leukemia (ALL) is a disease with poor prognosis and establishment of a novel treatment method is desired. We developed a treatment method by drug administration in vivo using a leukemia transplantation model for NSG immunodeficient mouse into which human cells can be transplanted. ALL-derived cell (HAL-01) when transplanted into NSG mouse and treated dose of anthracycline anticancer drug doxorubicin which induces DNA damage, NSG mouse is deficient in Prkdc and disrupted non-homologous end joining (NHEJ), because of its toxicity, he died soon. When cyclosporin, a drug transport pump (p-gp) inhibitor, was used in combination, the survival rate of leukemia transplanted mice was prolonged.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Invited: 2 results)

  • [Journal Article] HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy2017

    • Author(s)
      Takagi M, Ishiwata Y, Aoki Y, Miyamoto S, Hoshino A, Matsumoto K, Nishimura A, Tanaka M, Yanagimachi M, Mitsuiki N, Imai K, Kanegane H, Kajiwara M, Takikawa K, Mae T, Tomita O, Fujimura J, Yasuhara M, Tomizawa D, Mizutani S, Morio T.
    • Journal Title

      Int J Hematol

      Volume: 105 Issue: 5 Pages: 686

    • DOI

      10.1007/s12185-017-2187-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Haploidentical bone marrow transplantation with clofarabine and busulfan conditioning for a child with multiple recurrent acute lymphoblastic leukemia2016

    • Author(s)
      Aoki Y, Miyawaki R, Imai K, et al.
    • Journal Title

      J Pediatr Hematol Oncol.

      Volume: 38 Issue: 1 Pages: e39-e41

    • DOI

      10.1097/mph.0000000000000454

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 再発・難治ALLに対するキメラ抗原受容体発現T細胞(CAR-T)療法の有効性2016

    • Author(s)
      青木由貴,小川千登世
    • Journal Title

      血液内科

      Volume: 72 Pages: 452-456

    • Related Report
      2016 Annual Research Report
  • [Journal Article] MLL転座型ヒト急性リンパ性白血病におけるleukemia initiating cellsの同定2016

    • Author(s)
      青木由貴, 高木 正稔, 小野 林太郎, 水谷 修紀, 石川 文彦
    • Journal Title

      血液内科

      Volume: 72 Pages: 231-236

    • NAID

      40020749788

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] ヒト化マウスシステムを用いた,成人および乳児白血病の病態解明2015

    • Author(s)
      小野林太郎、青木由貴、水谷修紀、石川文彦
    • Journal Title

      日本小児血液・がん学会雑誌

      Volume: 52 Pages: 376-380

    • NAID

      130005125270

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Introduce my article2015

    • Author(s)
      青木由貴
    • Journal Title

      臨床血液

      Volume: 56 Pages: 225-225

    • Related Report
      2015 Research-status Report
  • [Presentation] Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.2016

    • Author(s)
      青木 由貴
    • Organizer
      第58回日本小児血液・がん学会学術集会(学術賞受賞招待講演)
    • Place of Presentation
      品川プリンスホテル(東京都港区)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 小児再発・難治リンパ系腫瘍に対するボルテゾミブを含む多剤併用療法の後方視的調査.2016

    • Author(s)
      青木 由貴、荒川 歩、熊本 忠史、小川千登世
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Xenograftを用いた乳児期発症のMLL白血病の病態理解2015

    • Author(s)
      青木 由貴、小野 林太郎、佐藤 馨、高木 正稔、水谷 修紀、石川 文彦
    • Organizer
      第11回麒麟塾
    • Place of Presentation
      コクヨホール(東京都港区)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Xenogragtを用いたMLL白血病の病態理解2015

    • Author(s)
      青木由貴
    • Organizer
      第13回 先端血液セミナー
    • Place of Presentation
      帝国ホテル東京(東京都千代田区)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Research-status Report
    • Invited

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi