Understanding of MLL-related leukemogenesis and identification of new therapeutic targets
| Project/Area Number |
15K19601
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Aoki Yuki 東京医科歯科大学, 医学部附属病院, 非常勤講師 (90706839)
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| Research Collaborator |
TAKAGI Masatoshi 東京医科歯科大学, 茨城県小児・周産期地域医療学講座, 准教授 (10406267)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | NSGマウス / 異種移植 / MLL / ALL / DNA修復機構 / ＮＳＧマウス / 乳児白血病 / 疾患モデル / 白血病幹細胞 |
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| Outline of Final Research Achievements |
MLL-rearranged infantile acute lymphocytic leukemia (ALL) is a disease with poor prognosis and establishment of a novel treatment method is desired. We developed a treatment method by drug administration in vivo using a leukemia transplantation model for NSG immunodeficient mouse into which human cells can be transplanted. ALL-derived cell (HAL-01) when transplanted into NSG mouse and treated dose of anthracycline anticancer drug doxorubicin which induces DNA damage, NSG mouse is deficient in Prkdc and disrupted non-homologous end joining (NHEJ), because of its toxicity, he died soon. When cyclosporin, a drug transport pump (p-gp) inhibitor, was used in combination, the survival rate of leukemia transplanted mice was prolonged.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy.2017
Author(s)
Takagi M, Ishiwata Y, Aoki Y, Miyamoto S, Hoshino A, Matsumoto K, Nishimura A, Tanaka M, Yanagimachi M, Mitsuiki N, Imai K, Kanegane H, Kajiwara M, Takikawa K, Mae T, Tomita O, Fujimura J, Yasuhara M, Tomizawa D, Mizutani S, Morio T.
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Journal Title
Int J Hematol
Volume: 105
Issue: 5
Pages: 686-691
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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