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Establishment the novel treatment strategy from the analysis of MLL gene rearranged refractory infantile leukemia

Research Project

Project/Area Number 15K19605
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionKanazawa University

Principal Investigator

Ikawa Yasuhiro  金沢大学, 附属病院, 特任助教 (10722043)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords乳児白血病 / MLL遺伝子再構成 / 新規治療法開発 / 無治療自然寛解 / MLL遺伝子 / エピジェネティクス / MOZ遺伝子 / 自然寛解 / メチル化 / アポトーシス関連遺伝子 / CD10タンパク / MLL融合タンパク / 遺伝子導入
Outline of Final Research Achievements

We introduced MLL rearranged fusion gene into CD10 positive leukemic cell line. At first, we thought CD10 expression would shut down after transduction as typical infantile MLL-rearranged lymphocytic leukemia. However, CD10 did not turn into negative. The other factors would be related to this CD10 negativity phenomenon.
Next, we experienced congenital acute myeloid leukemia case who got into spontaneous remission without any therapy. We checked DNA, RNA and protein expression level and realized that RNA and protein expression levels were extremely low compared to DNA. This suppression phenomenon has not been reported so far. Continuous examination of this mechanism would shed light on the establishment the novel treatment strategy of refractory infantile leukemia.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Deep spontaneous molecular remission in a patient with congenital acute myeloid leukemia expressing a novel MOZ-p300 fusion transcript.2018

    • Author(s)
      Ikawa Y, Nishimura R, Maeba H, Fujiki T, Kuroda R, Noguchi K, Fukuda M, Mase S, Araki R, Mitani Y, Sato T, Terui K, Ito E, Kitabayashi I, Yachie A.
    • Journal Title

      Leuk Lymphoma

      Volume: 印刷中 Issue: 10 Pages: 1-3

    • DOI

      10.1080/10428194.2018.1434885

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leopard skin appearance of cutaneous polyarteritis nodosa on 18Ffluorodeoxyglucose positron emission tomography.2016

    • Author(s)
      Shimizu M, Inoue N, Mizuta M, Ikawa Y, Yachie A.
    • Journal Title

      Rheumatology

      Volume: 22

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathognomonic serum cytokine profiles identify life-threatening langerhans cell histiocytosis.2016

    • Author(s)
      Ikawa Y, Nishimura R, Araki R, Noguchi K, Muraoka M, Fukuda M, Fujiki T, Kuroda R, Mase S, Maeba H, Nomura K, Yachie A.
    • Journal Title

      Br J Haematol.

      Volume: 4

    • NAID

      120005771099

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of exertional heat stroke using continuous plasma diafiltration.2015

    • Author(s)
      Inoue N, Sato A, Ikawa Y, Shimizu M, Okajima M, Taniguchi T, Yachie A
    • Journal Title

      J Clin Apher

      Volume: 17

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Spontaneous remission of congenital acute myeloid leukemia with novel MOZ-p300 fusion transcript2016

    • Author(s)
      伊川泰広
    • Organizer
      第58回日本小児血液・がん学会学術集会
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2016-12-15
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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