Establishment the novel treatment strategy from the analysis of MLL gene rearranged refractory infantile leukemia
Project/Area Number |
15K19605
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 乳児白血病 / MLL遺伝子再構成 / 新規治療法開発 / 無治療自然寛解 / MLL遺伝子 / エピジェネティクス / MOZ遺伝子 / 自然寛解 / メチル化 / アポトーシス関連遺伝子 / CD10タンパク / MLL融合タンパク / 遺伝子導入 |
Outline of Final Research Achievements |
We introduced MLL rearranged fusion gene into CD10 positive leukemic cell line. At first, we thought CD10 expression would shut down after transduction as typical infantile MLL-rearranged lymphocytic leukemia. However, CD10 did not turn into negative. The other factors would be related to this CD10 negativity phenomenon. Next, we experienced congenital acute myeloid leukemia case who got into spontaneous remission without any therapy. We checked DNA, RNA and protein expression level and realized that RNA and protein expression levels were extremely low compared to DNA. This suppression phenomenon has not been reported so far. Continuous examination of this mechanism would shed light on the establishment the novel treatment strategy of refractory infantile leukemia.
|
Report
(4 results)
Research Products
(5 results)
-
[Journal Article] Deep spontaneous molecular remission in a patient with congenital acute myeloid leukemia expressing a novel MOZ-p300 fusion transcript.2018
Author(s)
Ikawa Y, Nishimura R, Maeba H, Fujiki T, Kuroda R, Noguchi K, Fukuda M, Mase S, Araki R, Mitani Y, Sato T, Terui K, Ito E, Kitabayashi I, Yachie A.
-
Journal Title
Leuk Lymphoma
Volume: 印刷中
Issue: 10
Pages: 1-3
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Pathognomonic serum cytokine profiles identify life-threatening langerhans cell histiocytosis.2016
Author(s)
Ikawa Y, Nishimura R, Araki R, Noguchi K, Muraoka M, Fukuda M, Fujiki T, Kuroda R, Mase S, Maeba H, Nomura K, Yachie A.
-
Journal Title
NAID
Related Report
Peer Reviewed
-
-