Widespread white matter microstructural abnormalities related to cognitive impairment in bipolar disorder and major depressive disorder: A DTI study
| Project/Area Number |
15K19744
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 気分障害 / 白質微細構造異常 / 認知機能障害 / DTI / 治療抵抗性うつ病 / rTMS 治療 / ECT / 神経ネットワーク |
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| Outline of Final Research Achievements |
The FA of WM in widespread regions including CC in the BD, and MDD groups was significantly reduced compared with those in the HC group. The mean FA of the WM skeleton with statistical differences correlated with performance on the list learning in the BD group, and correlated with performance on the digit sequencing task, token motor, and symbol coding in the MDD group. Our results suggested widespread WM microstructural abnormalities, which were associated with cognitive impairment in patients with BD and MDD. This study contributes to the understanding of WM pathophysiology in BD and MDD.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Microstructural abnormalities in anterior callosal fibers and their relationship with cognitive function in major depressive disorder and bipolar disorder: A tract-specific analysis study2015
Author(s)
Yamada S, Takahashi S, Ukai S, Tsuji T, Iwatani J, Tsuda K, Kita A, Sakamoto Y, Yamamoto M, Terada M, Shinosaki K
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Journal Title
Journal of Affective Disorders
Volume: 174
Pages: 542-548
DOI
Related Report
Peer Reviewed
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