Investigation of the factor and drafting of the prophylaxis of the sudden death in schizophrenia and mood disorders patients.

Research Project

Project/Area Number	15K19745
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Dokkyo Medical University
Principal Investigator	Okayasu Hiroaki 獨協医科大学, 医学部, 講師 (80459619)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	向精神薬 / 心電図 / QT間隔延長 / 統合失調症 / 気分障害 / 突然死 / 心臓突然死 / QT間隔 / QT dispersion / Tpeak-end / 抗うつ薬 / 抗精神病薬 / 心電図異常 / QT dispertion
Outline of Final Research Achievements	A risk of fatal arrhythmia is high in a patient with psychotropic drug treatment. I reevaluated the risk to fatal arrhythmia prediction by the psychotropic drug using each indexes of electrocardiogram which were regarded more suitable than QT interval. . In mood disorder patients, lengthening of QT dispersion was correlated with tricyclic antidepressant with a dose-dependent manner. Furthermore, an average of QT dispersion length was significantly longer than those of normal controls. Because a schizophrenia patient had a high risk of sudden death, the expression level of particular mRNA in blood, in which mutation has been regarded as a risk of both QT prolongation and schizophrenia, was compared with those of normal controls. In the results, mRNA of AKAP9977 and KCNH2 gene level was lower than those of normal controls. However, NRG1 mRNA expression level was higher in schizophrenia than normal controls. The QT interval correlated with no mRNA expression level of any genes.