| Project/Area Number |
15K19771
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
Sato Hiro 群馬大学, 医学部附属病院, 医員 (90750571)
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 放射線腫瘍学 / 腫瘍免疫学 / 腫瘍免疫 / 放射線治療 / 炭素イオン線治療 / 放射線生物 |
|---|
| Outline of Final Research Achievements |
I found that carbon ion radiotherapy induced high-mobility group box 1 (HMGB1) release, and T cell activation and proliferation in mice with lymphoma.
HMGB1 is a member of damage-associated molecular pattern, which is released by irradiated tumor cells and trigger the activation of antigen presentation cells (APCs). APCs present the tumor-derived antigens to cytotoxic T lymphocytes, which then kill the target cells. Therefore, the present data suggested that tumor cell death by carbon ion radiotherapy elicited activation of tumor antigen specific immune response.
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