Anti cancer specific immune response after carbon ion irradiation
Project/Area Number |
15K19771
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Gunma University |
Principal Investigator |
Sato Hiro 群馬大学, 医学部附属病院, 医員 (90750571)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 放射線腫瘍学 / 腫瘍免疫学 / 腫瘍免疫 / 放射線治療 / 炭素イオン線治療 / 放射線生物 |
Outline of Final Research Achievements |
I found that carbon ion radiotherapy induced high-mobility group box 1 (HMGB1) release, and T cell activation and proliferation in mice with lymphoma. HMGB1 is a member of damage-associated molecular pattern, which is released by irradiated tumor cells and trigger the activation of antigen presentation cells (APCs). APCs present the tumor-derived antigens to cytotoxic T lymphocytes, which then kill the target cells. Therefore, the present data suggested that tumor cell death by carbon ion radiotherapy elicited activation of tumor antigen specific immune response.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation.2015
Author(s)
Yoshimoto Y, Oike T, Okonogi N, Suzuki Y, Ando K, Sato H, Noda SE, Isono M, Mimura K, Kono K, Nakano T
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Journal Title
J Radiat Res
Volume: 56
Issue: 3
Pages: 509-514
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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