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The new MRI brain volumetry method using compensation method for tissue denaturing

Research Project

Project/Area Number 15K19774
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKitasato University

Principal Investigator

Goto Masami  北里大学, 医療衛生学部, 講師 (30375844)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
KeywordsMRI(磁気共鳴画像) / 脳容積計測 / 老化 / アルツハイマー型認知症 / 核磁気共鳴画像 / 脳容積 / 鉄沈着 / ボクセルベース解析
Outline of Final Research Achievements

Voxel-based morphotometry (VBM) using the MR image is a method to measure the brain volume. The VBM method elucidates the local brain function in diseases such as Alzheimer's dementia or schizophrenia. The brain denaturation to occur because of the aging and a picture decline of the MR image reduces the precision of the VBM method. Many studies are conducted about the method to reduce influence by a picture, but a few studies are conducted about the method to correct for brain denaturation. Therefore I suggested technique to measure influence on picture by the brain denaturation and contributed to improvement of precision in VBM analysis.

Academic Significance and Societal Importance of the Research Achievements

新規本手法の構築はこれまでに取り入れられていない補正法を取り入れた新しい手法であり、疾患領域から脳機能解明領域までの幅広い分野で利用される脳容積評価の精度向上が実現できる。これまでの方法では疾患と関連のある脳領域を検出できなかったわずかな変化をとらえたり、本来容積変化が生じていないことを証明することが可能となった。この成果により、画像診断の精度を格段にあげ、バイオマーカーの探索、早期診断、さらには創薬開発などに貢献することが可能である。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Combining Segmented Grey and White Matter Images Improves Voxel-based Morphometry for the Case of Dilated Lateral Ventricles2018

    • Author(s)
      Goto M, Abe O, Aoki S, Kamagata K, Hori M, Miyati T, Gomi T, Takeda T.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 4 Pages: 293-300

    • DOI

      10.2463/mrms.mp.2017-0127

    • NAID

      130007496792

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mis-segmentation in voxel-based morphometry due to a signal intensity change in the putamen2017

    • Author(s)
      Goto M, Abe O, Miyati T, Aoki S, Gomi T, Takeda T
    • Journal Title

      Radiol Phys Technol

      Volume: 10 Issue: 4 Pages: 515-524

    • DOI

      10.1007/s12194-017-0424-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adverse effects of metallic artifacts on voxel-wise analysis and tract-based spatial statistics in diffusion tensor imaging.2017

    • Author(s)
      Goto M, Abe O, Hata J, Fukunaga I, Shimoji K, Kunimatsu A, Gomi T.
    • Journal Title

      Acta Radiol

      Volume: 58 Issue: 2 Pages: 211-217

    • DOI

      10.1177/0284185116641348

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Repeatability of Brain Volume Measurements Made with the Atlas-based Method from T1-weighted Images Acquired Using a 0.4 Tesla Low Field MR Scanner.2016

    • Author(s)
      Goto M, Suzuki M, Mizukami S, Abe O, Aoki S, Miyati T, Fukuda M, Gomi T, Takeda T.
    • Journal Title

      Magn Reson Med Sci

      Volume: 15 Pages: 365-370

    • NAID

      130005421025

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Head Motion and Correction Methods in Resting-state Functional MRI.2016

    • Author(s)
      Goto M, Abe O, Miyati T, Yamasue H, Gomi T, Takeda T.
    • Journal Title

      Magn Reson Med Sci

      Volume: 15 Pages: 178-186

    • NAID

      130005144166

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Head Motion and Correction Methods in Resting-state Functional MRI.2016

    • Author(s)
      Goto M, Abe O, Miyati T, Yamasue H, Gomi T, Takeda T.
    • Journal Title

      Magn Reson Med Sci.

      Volume: 未定

    • NAID

      130005144166

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repeatability of Brain Volume Measurements Made with the Atlas-based Method from T1-weighted Images Acquired Using a 0.4 Tesla Low Field MR Scanner.2016

    • Author(s)
      Goto M, Suzuki M, Mizukami S, Abe O, Aoki S, Miyati T, Fukuda M, Gomi T, Takeda T.
    • Journal Title

      Magn Reson Med Sci.

      Volume: 未定

    • NAID

      130005421025

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brain volumetry with three-dimensional T1-weighted magnetic resonance image2015

    • Author(s)
      Masami GOTO, Tsutomu GOMI, Tohoru TAKEDA
    • Journal Title

      Medical Imaging and Information Sciences

      Volume: 32 Pages: 93-95

    • NAID

      130005116568

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] The relationship between the contrasts of analyzed images and measured volumes with Statistic Parametric Mapping 12 in Synthetic MRI.2018

    • Author(s)
      K Takasu, M Goto, T Gomi, A Hgiwara, S Fujita, S Aoki.
    • Organizer
      The 18th TAMRT Annual Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DARTELを用いた脳画像の空間的標準化における病変のマスキング方法に関する検討2018

    • Author(s)
      藤野修也 後藤政実 刈間崚太 五味勉
    • Organizer
      第46回日本放射線技術学会秋季学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Statistical Parametric Mappingを用いたセグメンテーションにおける脳組織間コントラストの影響2018

    • Author(s)
      刈間崚太 後藤政実 藤野修也 五味勉
    • Organizer
      第46回日本放射線技術学会秋季学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2.Effect of Change in T1-contrast between Brain Tissues in Segmentation with Statistical Parametric Mapping.2018

    • Author(s)
      R Karima, M Goto, T Gomi.
    • Organizer
      The 26th TSRT Annual Conference
    • Related Report
      2017 Research-status Report
  • [Presentation] Repeatability of measured brain volume by the atlas-based method with T1-weighted images using a 0.4 tesla low-strength static magnetic field2017

    • Author(s)
      Goto M, Suzuki M, Mizukami S, et al.
    • Organizer
      第45回日本放射線技術学会秋季学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Missegmentation with voxel-based morphometry by change of signal intensity in the putamen2016

    • Author(s)
      Goto M, Abe O, Miyati T, et al.
    • Organizer
      第44回日本放射線技術学会秋季学術大会
    • Place of Presentation
      大宮
    • Related Report
      2016 Research-status Report
  • [Presentation] The evaluation of intrasubject correction method for signal inhomogeneity in longitudinal voxel-based morphometry2015

    • Author(s)
      Masami Goto, Fumio Yamashita, Atsushi Kawaguchi, Osamu Abe, Shigeki Aoki, Tosiaki Miyati, Tsutomu Gomi, Tohoru Takeda
    • Organizer
      第43回日本放射線技術学会秋季学術大会
    • Place of Presentation
      石川県金沢市(石川県文教会館)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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