Development of new diagnostic method for progressive supernuclear palsy using Heavily T2-weighted 3D-FLAIR sequence

• Project/Area Number: 15K19783
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagoya University
• Principal Investigator: Yamazaki Masahiro 名古屋大学, 医学部附属病院, 病院助教 (40595526)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 磁気共鳴画像法 / heavily T2強調3D－FLAIR / 放射線医学 / 脳白質線維 / Heavily T2強調 3D-FLAIR / Heavily T2強調3D-FLAIR

Outline of Final Research Achievements

In this study, we showed that enhancement around the organum vasculosum of the lamina terminalis (OVLT) was observed after intravenous administration of Gadolinium-based contrast agent (GBCA) using heavily T2-weighted 3D-FLAIR sequence developed by us, and that indicated leakage of GBCAs into the CSF space with glymphatic system.
Furthermore, we showed that cochlear endolymphatic hydrops (EH) was occasionally observed in control ears using heavily T2-weighted 3D-FLAIR sequence after intravenous administration of GBCAs.

Research Products

• [Journal Article] Appearance of the Organum Vasculosum of the Lamina Terminalis on Contrast-enhanced MR Imaging (2018)
  • Author(s): NAGANAWA Shinji, TAOKA Toshiki, KAWAI Hisashi, YAMAZAKI Masahiro, SUZUKI Kojiro
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 2 Pages: 132-137
  • DOI: 10.2463/mrms.mp.2017-0088
  • NAID: 130006685585
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Imaging of the endolymphatic space in patients with Meniere's disease. (2017)
  • Author(s): Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone
  • Journal Title: Auris Nasus Larynx. Volume: 17(30) Issue: 1 Pages: 142-147
  • DOI: 10.1016/j.anl.2017.02.002
  • Peer Reviewed / Open Access
• [Journal Article] Contrast-enhanced magnetic resonance pancreatography with gadoteridol by heavily T2-weighted three-dimensional fluid-attenuated inversion recovery: preliminary results in healthy subjects (2016)
  • Author(s): Suzuki K, Naganawa S, Furuhashi N, Yamazaki M, Ogawa H, Kawai H
  • Journal Title: Nagoya J Med Sci Volume: 78 Pages: 175-181
  • NAID: 120005756084
  • Peer Reviewed / Open Access
• [Remarks] 名古屋大学 放射線医学教室
  • URL: http://www.med.nagoya-u.ac.jp/rad/
• [Remarks] 名古屋大学 教員データベースシステム
  • URL: http://profs.provost.nagoya-u.ac.jp/view/html/100005957_ja.html