Investigation of the potential of new marker of breast cancer based on IVIM/non-Gaussian diffusion MRI
| Project/Area Number |
15K19786
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
Iima Mami 京都大学, 白眉センター, 特定助教 (60748797)
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| Research Collaborator |
Kataoka Masako 京都大学, 大学院医学研究科放射線医学講座, 助教
Yamamoto Akira 京都大学, 大学院医学研究科放射線医学講座, 助教
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | MRI / IVIM / 非ガウス拡散MRI / 乳腺腫瘍 / 拡散強調MRI / 腫瘍 |
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| Outline of Final Research Achievements |
Diffusion MRI is a method which can provide important information of the microstructure and blood microcirculation (perfusion) of tissue. Using images acquired in test objects and normal volunteers first we optimized imaging conditions for accurately calculating diffusion and perfusion parameters. The potential of a synthetic Apparent Diffusion Coefficient (sADC, introduced in an article published in the Radiology journal), which combines as a single marker information on multiple diffusion and perfusion parameters, was investigated. A prospective clinical study with a large number of breast tumor patients was performed, and the diagnostic ability of multiple diagnostic approaches including sADC was shown to be comparable to the conventional approach using injection of contrast agents (so called BI-RADS classification).
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Report
(4 results)
Research Products
(26 results)
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[Presentation] An investigation of the effect of breastfeeding on intravoxel incoherent motion (IVIM) and non-Gaussian diffusion MRI of the lactating breast.2018
Author(s)
Iima M, Kataoka M, Sakaguchi R, Kanao S, Onishi N, Kawai M, Murata K, Togash K.
Organizer
Joint Annual Meeting ISMRM-ESMRMB 2018. Joint Annual Meeting ISMRM-ESMRMB, France, Paris, 16-21 June 2018
Related Report
Int'l Joint Research
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[Presentation] Time makes the difference: Comparison of ADC values obtained with OGSE and PGSE sequences for differentiation of human breast tumors.2018
Author(s)
Iima M, Kataoka M, Kawai Miyake K, Honda M, Sakaguchi R, Ohno Kishimoto A, Suzuki M, Murata K, Feiweier T, Toi M, and Togashi K.
Organizer
Joint Annual Meeting ISMRM-ESMRMB 2018. Joint Annual Meeting ISMRM-ESMRMB, France, Paris, 16-21 June 2018
Related Report
Int'l Joint Research
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[Presentation] Quantitative non-Gaussian diffusion and IVIM MRI: Correlation between synthetic parameters and breast cancer biomarkers.2017
Author(s)
Iima M, Kataoka M, Kanao S, Onishi N, Kawai M, Ohashi S, Sakaguchi R, Ohno K A, Toi M, Togashi K.
Organizer
The 25th Annual Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine. USA, HI, Honolulu, 22-27 April 2017
Related Report
Int'l Joint Research
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[Presentation] Non-Gaussian diffusion MRI in evaluation of early treatment effects during neoadjuvant treatment for breast cancer.2015
Author(s)
Iima M, Ogino R, Kataoka M, Nagao S, Kanao S, Ohashi A, Kawai M, Onishi N, Togashi K, and Le Bihan D.
Organizer
The 74th annual meeting of the Japan Radiological Society
Place of Presentation
Yokohama, Japan
Year and Date
2015-04-16
Related Report
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