Evaluation of lesions in multiple screlosis using diffusion kurtosis imaging and quantitative susceptibility mapping.

• Project/Area Number: 15K19812
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: SUZUKI masako 岩手医科大学, 医学部, 助教 (10616402)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Multiple Sclerosis / MRI / diffusion-tensor image / SWI / DKI / QSM / BRB-N / Multiple Sclelosis / diffuse kurtosis imaging / voxel-based morphometry / 多発性硬化症 / 高次脳機能障害

Outline of Final Research Achievements

In this study, we attempted to improve early diagnosis and prognosis prediction, such as cognitive impairment, of multiple sclerosis by establishing objective evaluation methods of minimal brain lesions including normal-appearing white/gray matter. We used magnetic resonance imaging (MRI) diffusion kurtosis imaging and quantitative susceptibility mapping by 3T MRI, which were developed by us. We performed head MRI and higher brain function tests on 25 patients with multiple sclerosis (one of them withdrew due to pregnancy) successively at baseline and after 6, 12, 18, and 24 months. We plan to continue the evaluation of prognostic factors by comparatively analyzing factors such as disease duration, severity, location of lesions, and degree of brain atrophy.