Development of new chemotherapeutic agent for hepatocellular carcinoma focused on the calcium homeostasis.
Project/Area Number |
15K19873
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | The University of Tokyo |
Principal Investigator |
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Research Collaborator |
OKU Yusuke 岩手医科大学, 薬学部, 助教
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 肝細胞癌 / 化学療法 / カルシウム / ホメオスタシス |
Outline of Final Research Achievements |
Development of effective chemotherapy is an important task for the improvement of frequent recurrence of hepatocellular carcinoma (HCC). In this study, the screening system of chemical compound using human embryonic lung fibroblast (HEL cell) was established. As the result of screening, thapsigargin (Ca2+-ATPase inhibitor) was clarified to have a particular cytotoxic effect against proliferative cells. Thapsigargin showed the cytotoxic effect against various HCC cell lines. This growth inhibitory effect was detected in the in vivo trials using hepatoma model mouse. These results suggest that Ca2+-ATPase inhibitor might be useful in the chemotherapy for HCC.
|
Report
(3 results)
Research Products
(9 results)
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[Journal Article] Preliminary investigation of five novel long non-coding RNAs in hepatocellular carcinoma cell lines2016
Author(s)
Xia J, Inagaki Y, Sawakami T, Song P, Cai Y, Hasegawa K, Sakamoto Y, Akimitsu N, Tang W, Kokudo N.
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Journal Title
BioScience Trends
Volume: 10
Issue: 4
Pages: 315-319
DOI
NAID
ISSN
1881-7815, 1881-7823
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Preclinical study of c-Met inhibitor as an adjuvant treatment for hepatocellular carcinoma with macroscopic portal vein invasion.2017
Author(s)
Kokudo T, Inagaki Y, Hasegawa K, Shirata C, Amikura K, Takahashi A, Kaneko J, Akamatsu N, Arita J, Sakamoto Y, Kokudo N.
Organizer
2017 Gastrointestinal Cancers Symposium.
Place of Presentation
サンフランシスコ、アメリカ
Year and Date
2017-01-19
Related Report
Int'l Joint Research
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[Presentation] Inhibition of human hepatoma-cell-line tumor growth by near infrared photodynamic therapy with indocyanine green.2015
Author(s)
Inagaki Y, Kaneko J, Shirata C, Kokudo T, Yamamoto S, Akamatsu N, Arita J, Tang W, Sakamoto Y, Hasegawa K, Kokudo N.
Organizer
第15回東京大学生命科学シンポジウム
Place of Presentation
東京
Year and Date
2015-06-27
Related Report