Characterization of the T cell repertoire by deep T cell receptor sequencing in tissues and blood from patients with advanced colorectal cancer treated with cetuximab.

Research Project

Project/Area Number	15K19894
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	Yamaguchi University
Principal Investigator	INOUE Yuka 山口大学, 医学部附属病院, 診療助教(4日/週) (50749835)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	癌免疫学 / 進行大腸癌 / セツキシマブ / TCRレパートリー / TCR-α / TCR-β / 多様性 / 切除不能進行大腸癌 / TCR / TCR解析
Outline of Final Research Achievements	We started this study, after approval of IRB (Institutional Review Board). Three cases were enrolled this study by now. During this study period, we published a paper of the study which was the opportunity to start this study. Furthermore, we published a paper and reported about analyzing the T cell repertoire in blood samples and cancer tissues in advanced colorectal cancer patients that had received cancer peptide vaccine and oxaliplatin-based chemotherapy, and investigating the relationship between the TCR diversity and the PFS (progression free survival).

Report

(3 results)