Clarification the molecular mechanism of chemotherapy-related sinusoidal obstructive syndrome and the study for efficacy of anti–vascular endothelial growth factor therapy.
| Project/Area Number |
15K19898
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
KUROKI Hideyuki 熊本大学, 医学部附属病院, 非常勤診療医師 (50594876)
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| Research Collaborator |
HAYASHI Hiromitsu 熊本大学, 医学部附属病院, 非常勤診療医師 (80625773)
HIGASHI Takaaki 熊本大学, 医学部附属病院, 非常勤診療医師 (70594878)
NAKAGAWA Shigeki 熊本大学, 医学部附属病院, 特任助教 (10594872)
YAMAMURA Kensuke 熊本大学, 医学部附属病院, 非常勤診療医師
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 大腸癌肝転移 / 肝類洞閉塞症候群 / oxaliplatin / Thrombospondin-1（TSP-1） / bevacizumab / 肝中心静脈閉塞症 / TSP-1 |
|---|
| Outline of Final Research Achievements |
TSP-1 was involved in the proliferation of human umbilical vein endothelial cells (HUVEC). However, when oxaliplatin was administered to HUVEC, expression of TSP-1 was not induced. In immunostaining of TSP-1 in specimen of colorectal cancer liver metastases receiving oxaliplatin with or without bevacizumab, there was no significant difference in the expression of TSP-1 between the two groups. The possibility that the expression of TSP-1 is involved in development of SOS is low.
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Report
(3 results)
Research Products
(2 results)
