The involvement of profibrogenic factors in the malignant behavior of cholangiocarcinoma
| Project/Area Number |
15K19914
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Research Collaborator |
Uyama Naoki 兵庫医科大学, 医学部, 講師 (70402873)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 肝内胆管癌 / fibroblasts / profibrogenic factors / PDGFs / CTGF / 線維芽細胞 / Profibrogenic factor / PDGF |
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| Outline of Final Research Achievements |
The presence of cancer associated fibroblasts and collagens ( Type I, III and IV) was found in the stroma of intrahepatic cholangiocarcinoma (ICC) tissues. Immunoreactivity of PDGFs , CTGF and PDGF receptor (PDGFR) -α, -βwas found not only in cancer cells, but also in cancer associated fibroblasts. In in vitro experiments, two kinds of PDGFR inhibitor reduced proliferation of 2 types of ICC cell lines, indicating that PDGFs derived from cancer cells may stimulate their proliferation in an autocrine manner.
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Report
(4 results)
Research Products
(1 results)
