Functional analysis of cell cycle-related protein BubR1 in intimal hyperplasia lesions

• Project/Area Number: 15K19924
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Kyushu University
• Principal Investigator: KYURAGI Ryoichi 九州大学, 医学研究院, 共同研究員 (20631592)
• Research Collaborator: TANAKA Shinichi
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 動脈硬化 / 内膜肥厚 / BubR1 / AopE

Outline of Final Research Achievements

【Background】BubR1 is a cell cycle-related protein. We generated BubR1L/L-ApoE-/- mice to examin the role of BubR1 in arteriosclerosis.【Methods and Results】The arteriosclerotic lesion was significantly suppressed in BubR1L/L-ApoE-/- mice and the accumulation of macrophages was decreased as compared with ApoE -/- mice. Bone marrow-derived cells and non-bone marrow-derived cells of BubR1 were involved in suppression of arteriosclerosis. There was no significant difference in the migratory ability of bone marrow-derived macrophages, but the proliferative capacity was decreased in BubR1L/L-ApoE-/- mice. 【Conclusions】BubR1 may be a target for new treatments to suppress arteriosclerosis.

Research Products

• [Journal Article] BubR1 insufficiency inhibits neointimal hyperplasia through impaired vascular smooth muscle cell proliferation in mice (2015)
  • Author(s): Kyuragi, R., Matsumoto, T., Harada, Y., Saito, S., Onimaru, M., Nakatsu, Y., Tsuzuki, T., Nomura, M., Yonemitsu, Y., Maehara, Y.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. Volume: 35 Issue: 2 Pages: 341-347
  • DOI: 10.1161/atvbaha.114.304737
  • Peer Reviewed / Open Access