Clarification of the mechanism of drug resistance focused on microRNAs associated with epithelial-mesenchymal transition in lung cancer
Project/Area Number |
15K19935
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory surgery
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Research Institution | Okayama University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 原発性肺癌 / 薬剤耐性機構 / マイクロRNA / 上皮間葉移行 / 肺癌 / 上皮間葉系移行 |
Outline of Final Research Achievements |
It is a challenge to overcome the acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKI) in lung cancers harboring EGFR activating mutations. Epithelial-mesenchymal transition (EMT), which was one of the mechanisms of the acquired resistance to EGFR-TKI, was associated with miR-200, one of microRNAs. In addition, the expression of LIN28B gene was elevated in EGFR-TKI-resistant lung cancer cell lines. Cell proliferation was inhibited by the induction of miR-200c or the knockdown of LIN28B in EGFR-TKI-resistant lung cancer cell lines. Thus, it is considered that LIN28B was a potential therapeutic target for lung cancer with the acquired resistance to EGFR-TKI.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.2017
Author(s)
Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 40847-40847
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Targeting miR-200c/Lin28B axis in acquired EGFR-TKI resistance non-small cell cancer cells harboring EMT features2016
Author(s)
Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyota
Organizer
World Conference on Lung Cancer 2016
Place of Presentation
Vienna, Austria
Year and Date
2016-12-04
Related Report
Int'l Joint Research