Experimental study on the lung transplantation monitoring using a bronchoscopic microsampling

• Project/Area Number: 15K19944
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Keio University
• Principal Investigator: Sakamaki Hiroyuki 慶應義塾大学, 医学部(信濃町), 助教 (10749104)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肺移植 / 気管支断端 / 酸素分圧 / 気管支断端酸素分圧 / 酸素分圧モニター / マイクロサンプリング法

Outline of Final Research Achievements

The purpose of this study was to explore the mechanisms of the lung injury marker in pig lung transplantation using Bronchoscopic micro sampling. However, the recipient often died after lung transplantation in a few hours. We estimate that one of the cause of the failure is ischemia of the bronchial suture part. To test the hypothesis, we focus on the tissue oxygen concentration of the bronchial suture part. We measured the tissue oxygen concentration of eight points of a bronchial stump and remaining main bronchus. The results of the study show that tissue oxygen concentration of medial - proximal parts tended to be higher than that of lateral - distal parts. It is difficult to measure an accurate　tissue oxygen concentration of the bronchial suture part. In the future, we need to improve the device and the accumulation of data of animal studies to get useful information for lung transplantation.

Research Products

• [Journal Article] Dry pleurisy complicating solitary pulmonary nodules caused by Mycobacterium avium: a case report. (2015)
  • Author(s): Asakura T, Ishii M, Haraguchi M, Kamiyama I, Kohno M, Sakamaki H, Emoto K, Hayashi Y, Sugiura H, Kawada I, Soejima K, Namkoong H, Tasaka S, Hasegawa N, Betsuyaku T.
  • Journal Title: J Med Case Rep. Volume: Oct 26;9:238. Issue: 1 Pages: 238-238
  • DOI: 10.1186/s13256-015-0723-4
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary arterial enlargement predicts cardiopulmonary complications after pulmonary resection for lung cancer: a retrospective cohort study. (2015)
  • Author(s): Asakura K, Mitsuboshi S, Tsuji M, Sakamaki H, Otake S, Matsuda S, Kaseda K, Watanabe K.
  • Journal Title: J Cardiothorac Surg. Volume: Sep 9;10:113. Issue: 1
  • DOI: 10.1186/s13019-015-0315-9
  • Peer Reviewed / Open Access
• [Presentation] Is FDG-PET useful for distinguishing between thymic epithelial tumors and malignant lymphoma？ (2016)
  • Author(s): Hiroyuki Sakamaki , Takashi Otsuka , Yota Suzuki , Shoji Kuriyama , Kenichi Hamada , Toshiyuki Shima , Masaya Yotsukura Kyohei Masai , Kaoru Kaseda , Hisao Asamura
  • Organizer: IASLC 17th world conference on lung cancer
  • Place of Presentation: Vienna , Austria
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] 前縦隔悪性リンパ腫と胸腺上皮性腫瘍の鑑別における FDG-PET/CTの有用性の検討 (2016)
  • Author(s): 坂巻寛之 , 大塚 崇 , 鈴木陽太 , 栗山翔司 , 濱田賢一 , 志満敏行 , 四倉正也 政井恭兵 , 木下智成 , 加勢田 馨 , 神山育男 , 淺村尚生
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館(京都府左京区）
  • Year and Date: 2016-05-12
• [Presentation] 間質性肺炎合併肺腫瘍に対する 凍結融解壊死療法 (2015)
  • Author(s): 坂巻寛之、朝倉啓介、志満敏行、松田信作、四倉正也、神山育男、 大塚 崇、屋代英樹、井上政則、中塚誠之、淺村尚生
  • Organizer: 第32回日本呼吸器外科学会総会
  • Place of Presentation: 香川国際会議場(香川県高松市）
  • Year and Date: 2015-05-14