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Quantitative evaluation of cerebral blood flow by enhanced arterial spin labeling (eASL) technique in patients with steno-occlusive disease

Research Project

Project/Area Number 15K19959
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionUniversity of Fukui

Principal Investigator

Isozaki Makoto  福井大学, 学術研究院医学系部門, 特別研究員 (60464054)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsarterial spin labeling / cerebral blood flow / Arterial spin labeling / Cerebral blood flow / Cerebrovascular disease / Arterial Spin Labeling / 脳血流量 / 脳血管障害 / ASL
Outline of Final Research Achievements

It is important for treatment of ischemic cerebrovascular disease to evaluate cerebral blood flow. IMP-SPECT and PET are golden standard for evaluation of cerebral blood flow today. On the other hand, the challenge for the quantitative evaluation of cerebral blood flow by the ASL was performed. We thought that how correct was the quantitative evaluation by the ASL compared with PET.This study aimed to investigate the accuracy of ASL technique for quantitative evaluation of CBF in comparison with PET. 14 patients who were performed carotid endarterectomy (CEA) at our hospital from February 2015 to April 2017. We set these inclusion or exclusion criteria and chose 5 patients. Although PCASL slightly overestimated regional CBF values, there was significant correlation between the quantitative CBF values obtained using ASL and PET in all ROI plots.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results)

  • [Journal Article] Cerebral hyperperfusion syndrome resulting in subarachnoid hemorrhage after carotid artery stenting.2016

    • Author(s)
      Isozaki M, Arai Y, Higashino Y, Okazawa H, Kikuta KI.
    • Journal Title

      Ann Nucl Med

      Volume: 30 Issue: 9 Pages: 669-674

    • DOI

      10.1007/s12149-016-1108-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] もやもや病に対する、Arterial spin labeling(ASL)法による定量的脳血流評価の検討2017

    • Author(s)
      東野芳史、磯﨑誠、有島英孝、小寺俊昭、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      STROKE2017
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] もやもや病に対する、Arterial spin labeling(ASL)法による定量的脳血流評価の検討2017

    • Author(s)
      東野芳史、磯﨑誠、竹内香代、金本雅行、有島英孝、小寺俊昭、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      日本脳神経CI学会 第40回
    • Place of Presentation
      鹿児島サンロイヤルホテル(鹿児島市)
    • Year and Date
      2017-03-03
    • Related Report
      2016 Research-status Report
  • [Presentation] もやもや病に対する、Arterial spin labeling(ASL)法による定量的脳血流評価の検討2017

    • Author(s)
      東野芳史、磯﨑誠、竹内香代、金本雅行、有島英孝、小寺俊昭、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      日本神経放射線学会 第46回
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都)
    • Year and Date
      2017-02-18
    • Related Report
      2016 Research-status Report
  • [Presentation] もやもや病に対するArterial spin labeling(ASL)法による定量的脳血流評価の検討2017

    • Author(s)
      東野芳史、磯崎誠、竹内香代、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      第46回日本放射線学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] もやもや病に対するArterial spin labeling(ASL)法による定量的脳血流評価の検討2017

    • Author(s)
      東野芳史、磯崎誠、竹内香代、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      第40回日本脳神経CI学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] もやもや病に対するArterial spin labeling(ASL)法による定量的脳血流評価の検討2017

    • Author(s)
      東野芳史、磯崎誠、有島英孝、小寺俊昭、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      STROKE2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] もやもや病における、Arterial spin labeling (ASL)法による血行力学的虚血評価の検討2017

    • Author(s)
      東野芳史、磯崎誠、有島英孝、小寺俊昭、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      第76回日本脳神経外科学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] もやもや病における、Arterial spin labeling (ASL)法による血行力学的虚血評価の検討2017

    • Author(s)
      東野芳史、磯崎誠、有島英孝、小寺俊昭、北井隆平、菊田健一郎
    • Organizer
      STROKE2018
    • Related Report
      2017 Annual Research Report
  • [Presentation] もやもや病に対する、Arterial spin labeling(ASL)法による定量的脳血流評価の検討2016

    • Author(s)
      東野芳史、磯﨑誠、赤澤愛弓、山田真輔、荒井大志、常俊顕三、松田謙、有島英孝、小寺俊昭、北井隆平、木村浩彦、菊田健一郎
    • Organizer
      日本脳神経外科学会 第75回 学術総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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