| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Neurovascular Unit, the concept that not only neuron but also surrounding cells including glia and endothelial cells are needed to investigate ischemic stroke, has been regarded as an important concept. Ischemic preconditioning (IPC) is one of the stress to gain ischemic tolerance. We focused on vascular endothelial cells that detect vascular flow change during IPC. We revealed that P2X4 receptor on the vascular endothelial cells detect blood shear stress and induced ischemic tolerance via neuroprotective molecule osteopontin.
|
