The P2X4 receptor is required for neuroprotection via ischemic preconditioning
Project/Area Number |
15K19965
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
OZAKI TOMOHIKO 大阪大学, 医学系研究科, 招へい教員 (00723123)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | P2X4 receptor / オステオポンチン / 虚血耐性 / 血管内皮細胞 / P2X4受容体 / 脳虚血耐性 / 側副血行路 / 脳軟膜吻合 |
Outline of Final Research Achievements |
Neurovascular Unit, the concept that not only neuron but also surrounding cells including glia and endothelial cells are needed to investigate ischemic stroke, has been regarded as an important concept. Ischemic preconditioning (IPC) is one of the stress to gain ischemic tolerance. We focused on vascular endothelial cells that detect vascular flow change during IPC. We revealed that P2X4 receptor on the vascular endothelial cells detect blood shear stress and induced ischemic tolerance via neuroprotective molecule osteopontin.
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Report
(4 results)
Research Products
(5 results)