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Integrated analysis of metabolomics and genetics using cerebrospinal fluid of glioma patients

Research Project

Project/Area Number 15K19970
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKobe University

Principal Investigator

Nakamizo Satoshi  神戸大学, 医学研究科, 医学研究員 (00569238)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsメタボローム解析 / グリオーマ / IDH変異 / 2HG / Cerebrospinal fluid / microRNA / metabolome
Outline of Final Research Achievements

Using gas chromatography/mass spectorometry, metabolome analysis of cerebrospinal fluid of 53 patients was performed。And isocitrate dehydrogenase (IDH) mutation of the tumor was examined. The mean concentration of 2-hydroxygulitarate (2HG) in the CSF was 0.48mM. The mean concentration of 2HG in glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, and olifodendroglioma were 0.41mM, 0.46 mM, 0.71 mM, and 0.49 mM, respectively. There was no significant difference among tumor pathology. There were 11 cases with IDH mutation. In IDH mutation group, the mean concentration of 2HG was 0.61±0.2mM, on the other hand, in IDH wild-type group, the mean concentration of 2HG was 0.44±0.06mM. There was no significant difference of 2HG concentration between IDH mutation group and IDH wild-type group. These results indicate that 2HG concentration of CSF is not useful biomarker for the glima patients.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Radiographic occult cerebellar germinoma presenting with progressive ataxia and cranial nerve palsy.2016

    • Author(s)
      Minami N, Tanaka K, Kimura H, Hirose T, Mori T, Maeyama M, Sekiya H, Uenaka T, Nakamizo S, Nagashima H, Mizukawa K, Itoh T, Sasayama T, Kohmura E.
    • Journal Title

      BMC Neurol.

      Volume: 16 Issue: 1 Pages: 1-4

    • DOI

      10.1186/s12883-015-0516-9

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-Associated Macrophages Associate with Cerebrospinal Fluid Interleukin-10 and Survival in Primary Central Nervous System Lymphoma (PCNSL)2015

    • Author(s)
      Sasayama T, Tanaka K, Mizowaki T, Nagashima H, Nakamizo S, Tanaka H, Nishihara M, Mizukawa K, Hirose T, Itoh T, Kohmura E
    • Journal Title

      Brain Pathol.

      Volume: Aug 28 Issue: 4 Pages: 1-9

    • DOI

      10.1111/bpa.12318

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A 40-Year-Old Female with Leptomeningeal Lesions.2015

    • Author(s)
      Mizowaki T, Sasayama T, Semba S, Sasaki R, Yasuo K, Nakamizo S, Tanaka K, Mizukawa K, Uchihashi Y, Kohmura E.
    • Journal Title

      Brain Pathol.

      Volume: 25 Issue: 4 Pages: 509-10

    • DOI

      10.1111/bpa.12270

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma.2015

    • Author(s)
      Mizowaki T, Sasayama T, Tanaka K, Mizukawa K, Takata K, Nakamizo S, Tanaka H, Nagashima H, Nishihara M, Hirose T, Itoh T, Kohmura E
    • Journal Title

      J Neurooncol

      Volume: 124(2) Issue: 2 Pages: 165-74

    • DOI

      10.1007/s11060-015-1843-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 破裂脳動脈瘤に対するコイル塞栓術後2日目に後腹膜血腫を来した1例2017

    • Author(s)
      中村直人, 中溝聡、阪上義雄
    • Organizer
      第42回日本脳卒中学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 80歳以上の高齢者頚動脈狭窄症に対する頚動脈ステント留置術(CAS)の長期予後2017

    • Author(s)
      阪上義雄、中溝聡
    • Organizer
      第42回日本脳卒中学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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