| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Using gas chromatography/mass spectorometry, metabolome analysis of cerebrospinal fluid of 53 patients was performed。And isocitrate dehydrogenase (IDH) mutation of the tumor was examined. The mean concentration of 2-hydroxygulitarate (2HG) in the CSF was 0.48mM. The mean concentration of 2HG in glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, and olifodendroglioma were 0.41mM, 0.46 mM, 0.71 mM, and 0.49 mM, respectively. There was no significant difference among tumor pathology. There were 11 cases with IDH mutation. In IDH mutation group, the mean concentration of 2HG was 0.61±0.2mM, on the other hand, in IDH wild-type group, the mean concentration of 2HG was 0.44±0.06mM. There was no significant difference of 2HG concentration between IDH mutation group and IDH wild-type group. These results indicate that 2HG concentration of CSF is not useful biomarker for the glima patients.
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