Development of novel therapy targeting for B7 family on glioma cancer stem cells

• Project/Area Number: 15K19983
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kansai Medical University
• Principal Investigator: IWATA Ryoichi 関西医科大学, 医学部, 助教 (60580446)
• Research Collaborator: Nakano Ichiro
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: グリオーマ / 癌幹細胞 / 免疫治療 / B7 family / 膠芽腫

Outline of Final Research Achievements

This study is aimed to reveal the role of ICOS ligand in glioblastoma development. We have revealed that mesenchymal type glioma cancer stem cells express the ICOS ligand. Expression of ICOS ligand is associated with poor prognosis. Moreover, ICOS ligand promote the expansion of IL-10 producing T cells in the tumor microenvironment.

Research Products

• [Journal Article] Application of transpulmonary thermodilution monitoring (PiCCO) in patients with neurogenic pulmonary edema and acute obstructive hydrocephalus due to a central neurocytoma: A case report. (2017)
  • Author(s): R Iwata, K Yoshimura, Y Fujita, T Uesaka, H Oshige, A Asai
  • Journal Title: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management Volume: 8 Pages: 57-59
  • DOI: 10.1016/j.inat.2017.01.014
  • Peer Reviewed / Open Access
• [Journal Article] Hyperperfusion syndrome after clipping of an unruptured aneurysm by transsylvian approach: A Case Repot. (2017)
  • Author(s): R Iwata, K Yoshimura, Y Fujita, T Uesaka, H Oshige, A Asai
  • Journal Title: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. Volume: 8 Pages: 11-13
  • DOI: 10.1016/j.inat.2017.01.010
  • Peer Reviewed / Open Access
• [Journal Article] Serine/Threonine kinase MLK4 determines Mesenchymal Identity in Glioma Stem Cells in an NFkB-dependent manner (2016)
  • Author(s): Kim SH, Ezhilarasan R, Chhipa R, Ladner K, Phillips E, Sparks A, Taylor D, Furuta T, Sabit H, Kurozumi K, Kuroiwa T, Akio A, Gallego-Perez1 D, Sulman EP, Cheng S, Lee J, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Walker J, Nakano I.
  • Journal Title: Cancer Cell Volume: 29 Issue: 2 Pages: 201-213
  • DOI: 10.1016/j.ccell.2016.01.005
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 治療後長期間生存している悪性視神経膠腫の1 例. (2016)
  • Author(s): 藤原望, 中内正志, 正健一郎, 山田晴彦, 最所千晶, 岩田亮一, 亀井孝昌, 淺井昭雄, 髙橋寛二
  • Journal Title: 臨床眼科 Volume: 70 Pages: 1473-1478
  • Peer Reviewed
• [Journal Article] MESENCHYMAL TYPE GLIOMA STEM CELL EXPRESS ICOS LIGAND AND UPREGULATE ICOS+IL-10+ T CELLS (2015)
  • Author(s): Ryoichi Iwata, Tomoki Ito, Muneo Inaba, Taro Koike, Hideyuki Oshige, Kunikazu Yoshimura, Masahiro Nonaka, Hisao Yamada, Shosaku Nomura, Umberrto Dianzani, Ichiro Nakano, Akio Asai
  • Journal Title: Neuro-Oncology Volume: 17 Issue: suppl 5 Pages: 113-123
  • DOI: 10.1093/neuonc/nov217.16
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 内視鏡下5アミノレブリン酸（5-ALA）蛍光診断（PDD）～連続45症例の検討～. (2016)
  • Author(s): 武田純一, 埜中正博, 亀井孝昌, 岩田亮一, 羽柴哲夫, 吉村晋一, 淺井昭雄.
  • Organizer: 第34回日本脳腫瘍学会学術集会.
  • Place of Presentation: 甲府富士屋ホテル、山梨
  • Year and Date: 2016-12-04
• [Presentation] Effect of Temozolomide on Brain Metastasis of neuroendocrine carcinoma. (2016)
  • Author(s): Ryoichi Iwata, Masato Maruyama, Tomoki Ito, Yoko Fujita, Yoshiyuki Matsuo, Yosuke Nakano, Kunikazu Yoshimura, Masahiro Nonaka, Kiichi Hirota, Shosaku Nomura, Tetsuo Sugimoto, Akio Asai.
  • Organizer: The 13th Asian Society for Neuro-oncology (ASNO) Meeting.
  • Place of Presentation: Sheraton on the Park, Sydney, Australia
  • Year and Date: 2016-09-11
  • Int'l Joint Research
• [Presentation] Therapeutical Doses of Temozolomide Inhibit IL-10 Production by Dendritic Cells and Enhance the CTL Response. (2016)
  • Author(s): Akio Asai, Ryoichi Iwata, Tomoki Ito, Muneo Inaba, Noriko Katashiba, Kayoko Kibata, Akihiro Tanaka, Shosaku Nomura.
  • Organizer: The 21st International Conference on Brain Tumor Research and Therapy.
  • Place of Presentation: Bankoku Shinryokan, Okinawa, Japan
  • Year and Date: 2016-04-10
  • Int'l Joint Research
• [Presentation] グリオーマ癌幹細胞で発現するICOSリガンドを介した免疫制御機構の新展開 (2015)
  • Author(s): 岩田亮一, 伊藤量基, 稲葉宗夫, 小池太郎, 二宮英樹, 李一, 染野裕美子, 亀井孝昌, 武田純一, 大石哲也, 大重英行, 吉村晋一, 埜中正博, 山田久夫, 野村昌作, 中野伊知郎, 淺井昭雄
  • Organizer: 第33回日本脳腫瘍学会学術集会
  • Place of Presentation: 京都府京都市左京区宝ヶ池グランドプリンスホテル京都
  • Year and Date: 2015-12-06
• [Presentation] Mesenchymal type Glioma Stem Cell express ICOS Ligand and upregulate Tr1 cells (2015)
  • Author(s): Iwata R, Ito T, Inaba M, Koike T, Oshige H, Yoshimura K, Nonaka M, Yamada H, Nomura S, Dianzani U, Nakano I, Asai A
  • Organizer: the 20th Annual Scientific Meeting and Education Day of the Society for Neuro-Onclology
  • Place of Presentation: San Antonio,Texas, USA San Antonio Marriott Rivercenter
  • Year and Date: 2015-11-19
  • Int'l Joint Research
• [Presentation] Mesenchymal type Glioma Stem Cell express ICOS Ligand and upregulate ICOS+IL-10+Tcells (2015)
  • Author(s): 岩田亮一, 伊藤量基, 稲葉宗夫, 小池太郎, 大重英行, 吉村晋一, 埜中正博, 山田久夫, 野村昌作, 中野伊知郎, 淺井昭雄
  • Organizer: 第56回日本組織細胞化学会総会・学術集会
  • Place of Presentation: 大阪府枚方市新町関西医科大学枚方新キャンパス
  • Year and Date: 2015-10-03
• [Presentation] Therapeutical dose of Temozolomide inhibit IL-10 production by dendritic cells and enhance the CTL response (2015)
  • Author(s): Ryoichi Iwata, Tomoki Ito, Muneo Inaba, Noriko Katashiba, Kayoko Kibata, Akihiro Tanaka, Phan Thi Xuan Vien, Hideyuki Oshige, Kunikazu Yoshimura, Takehiro Suyama, Masahiro Nonaka, Shosaku Nomura, Akio Asai
  • Organizer: ASNO 2015 12th Meeting of the Asian Society for Neuro-Onclology
  • Place of Presentation: Pasay City Manila, Philippines Sofitel Philippine Plaza Hotel
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] Mesenchymal typeのグリーマ癌幹細胞で発現するICOSリガンドは、IL-10産生T細胞を誘導する (2015)
  • Author(s): 岩田亮一, 伊藤量基, 稲葉宗夫, 小池太郎, 大重英行, 吉村晋一, 埜中正博, 山田久夫, 野村昌作, 中野伊知郎, 淺井昭雄
  • Organizer: 第25回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京都千代田区神田駿河台ソラシティカンファレンスセンター
  • Year and Date: 2015-07-11
• [Presentation] 悪性神経膠腫におけるICOSリガンドを介した腫瘍免疫抑制機序について (2015)
  • Author(s): 岩田亮一, 伊藤量基, 小池太郎, 大重英行, 吉村晋一, 埜中正博, 山田久夫, 野村昌作, 中野伊知郎, 淺井昭雄
  • Organizer: 第33回日本脳腫瘍病理学会
  • Place of Presentation: 香川県高松市浜ノ町JRホテルクレメント高松
  • Year and Date: 2015-05-29
• [Book] 【脳腫瘍学-基礎研究と臨床研究の進歩-】 転移性脳腫瘍 転移性脳腫瘍の治療 (2016)
  • Author(s): 岩田亮一、淺井昭雄
  • Total Pages: 5
  • Publisher: 日本臨牀
• [Book] 中枢神経系感染症、脳神経外科救急ハンドブック 日本脳神経外科救急学会編 改訂第2版 (2015)
  • Author(s): 岩田亮一, 淺井昭雄
  • Total Pages: 400
  • Publisher: メディカ出版