| Project/Area Number |
15K19988
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Chiba Institute of Science (2016)
Tokyo Medical and Dental University (2015) |
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Principal Investigator |
Izu Yayoi 千葉科学大学, 危機管理学部, 講師 (90431949)
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| Research Collaborator |
AIDA Tomomi Massachusetts Institute of Technology, Research Scientist
BIRK David E. University of South Florida, Professor
KOCH Manuel University of Cologne
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | VI型コラーゲン / XII型コラーゲン / 骨形成 / 骨芽細胞 / 骨芽細胞ネットワーク / 骨の質の制御 / 骨芽細胞コミュニケーションネットワーク / 細胞間コミュニケーションネットワーク |
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| Outline of Final Research Achievements |
In this research, we aimed to elucidate the control mechanism of bone quality, focusing on regulation of bone forming osteoblast cell-cell communication. We have elucidated that lack of collagen VI or collagen XII induces osteoblast shape change thereby decreased bone quality. In this research, we found that cooperative regulation of collagens VI and XII form osteoblast cell-cell communication network.
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