| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In vivo pain experiments using the administration route similar to that used in clinical practice are important for the research of the mechanism of action of analgesic drugs. In this study, we investigated whether the ongoing pain can be evaluated by observing the response of the primary somatosensory area using flavoprotein fluorescence imaging, a method that uses the properties of endogenous flavoprotein. A pain model of carrageenan-induced inflammation was used. Thirty minutes after carrageenan injection the hindpaw withdrawal thresholds measured by the von Frey filaments decreased significantly. At the same time the response of the primary somatosensory area to the left hindpaw vibratory stimulation increased significantly. Administration of ketoprofen increased significantly hindpaw withdrawal thresholds and also decreased the response of the primary somatosensory area. These results suggest that in vivo pain can be measured by flavoprotein fluorescence imaging method.
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