Role of GLP-1 receptor in volatile anesthetic-induced postconditioning in mice.

• Project/Area Number: 15K20046
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: The University of Tokushima
• Principal Investigator: HAMAGUCHI Eisuke 徳島大学, 病院, 助教 (60709575)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 吸入麻酔薬 / イソフルラン / ポストコンディショニング / 心筋保護 / 虚血再灌流障害 / GLP-1 / 心筋保護作用 / GLP-1受容体

Outline of Final Research Achievements

We confirmed volatile anesthetic-induced and GLP-1-induced cardiac postconditioning protects against ischemia-reperfusion injury in mice. Additionally, our results show that volatile anesthetic-induced cardiac postconditioning protection is dependent on GLP-1 activation.

Research Products

• [Journal Article] Normothermic cardiopulmonary bypass in patient with Waldenstrom's macroglobulinemia and cryoglobulinemia: Case report. (2017)
  • Author(s): Siho Satomi, Asuka Kasai, Eisuke Hamaguchi, Yasuo M. Tsutsumi, and Katsuya Tanaka.
  • Journal Title: A&A Case Reports 2017 Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial. (2016)
  • Author(s): Tsutsumi R, Kakuta N, Kadota T, Oyama T, Kume K, Hamaguchi E, Niki N, Tanaka K, Tsutsumi YM
  • Journal Title: Journal of Anesthesia Volume: 30 Issue: 5 Pages: 842-849
  • DOI: 10.1007/s00540-016-2217-y
  • Peer Reviewed / Open Access
• [Journal Article] General anesthesia of a Japanese infant with Barber-Say syndrome: a case report. (2016)
  • Author(s): Eisuke Hamaguchi, Yasuo M. Tsutsumi, Katsuyoshi Kume, Yoko Sakai, Nami Kakuta, Yuta Uemura, Shinji Kawahito, and Katsuya Tanaka.
  • Journal Title: JA Clin Rep Volume: 2 Issue: 1
  • DOI: 10.1186/s40981-016-0033-x
  • NAID: 120006939618
  • Peer Reviewed / Open Access
• [Journal Article] Anesthetic management of a patient with unruptured sinus of Valsalva aneurysm with right ventricular outflow tract obstruction. (2016)
  • Author(s): Naoji Mita, Shinji Kawahito, Tomohiro Soga, Toshiko Katayama, Narutomo Wakamatsu, Tomiya Kawahara, Nami Kakuta, Eisuke Hamaguchi, Yasuo M. Tsutsumi, Katsuya Tanaka, Kazumi Takaishi, and Hiroshi Kitahata.
  • Journal Title: Circ Cont Volume: 37 Pages: 195-198
  • NAID: 130005187639
  • Peer Reviewed
• [Journal Article] Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolins-3 expression. (2015)
  • Author(s): Eisuke Hamaguchi, Katsuya Tanaka, Rie Tsutsumi, Yoko Sakai, Kohei Fukuta, Asuka Kasai, and Yasuo M. Tsutsumi
  • Journal Title: Eur Rev Med Pharmacol Sci Volume: 19 Pages: 1285-1290
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 侵襲時の代謝破綻と糖負荷の影響 (2016)
  • Author(s): 堤保夫、香留希実子、笠井飛鳥、濵口英佑、酒井陽子、田中克哉
  • Organizer: 第63回日本麻酔科学会
  • Place of Presentation: マリンメッセ福岡（福岡県・福岡市）
• [Presentation] イソフルランによる心筋保護作用はSirtによるOpa-1制御を介する (2016)
  • Author(s): 堤保夫、香留希実子、濵口英佑、酒井陽子、北畑洋、田中克哉
  • Organizer: 第63回日本麻酔科学会
  • Place of Presentation: マリンメッセ福岡（福岡県・福岡市）
• [Presentation] AS患者の非心臓手術の麻酔 (2016)
  • Author(s): 田中克哉、濵口英佑、堤保夫
  • Organizer: 第63回日本麻酔科学会
  • Place of Presentation: マリンメッセ福岡（福岡県・福岡市）
• [Presentation] 腹部の局所混合血酸素飽和度モニタリング下に周術期管理を行った一例 (2016)
  • Author(s): 濵口英佑、福田浩平、久米克佳、堤保夫、田中克哉
  • Organizer: 第53回日本麻酔科学会中国・四国支部学術集会
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
• [Presentation] 術前の経口補水が患者の代謝状態に及ぼす効果 (2016)
  • Author(s): 濵口英佑、堤保夫、神邊紀子、角田奈美、田中克哉
  • Organizer: 第36回日本臨床麻酔学会
  • Place of Presentation: かるぽーと高知（高知県・高知市）
• [Remarks] 徳島大学医学部麻酔・疼痛治療医学分野 業績集
  • URL: http://tokudaimasui.jp/study/