• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Therapeutic effects to neuropathic pain by inhibition of STAT1 phosphorization

Research Project

Project/Area Number 15K20047
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionEhime University

Principal Investigator

Nishihara Tasuku  愛媛大学, 医学部附属病院, 助教 (50568912)

Research Collaborator TANAKA Junya  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsマイクログリア活性化 / マイクログリア / 神経保護
Outline of Final Research Achievements

We investigated the therapeutic effects of Chemical X to nerve injury and neuropathic pain. Chemical X didn't have significant effects to inhibition of STAT1 phosphorization in CCI rats. But PSD95, one of neuronal marker, was significantly increased and microglial activation was significantly suppressed in Chemical X administered group. In spinal cord, activated microglia was observed not only in posterior horn but also in anterior horn. Activated microglia with flattened shape intimately attached to large neurons in anterior horn, while those in the left posterior horn displayed amoeboid-like shape and the attachment to neurons was not apparent. We are continuously investigating therapeutic effects of Chemical X and focusing to the difference of activation of microglia in spinal cord.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.2017

    • Author(s)
      Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI.
    • Journal Title

      Brain, Behavior, and Immunity.

      Volume: 60 Pages: 282-292

    • DOI

      10.1016/j.bbi.2016.11.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi