Therapeutic effects to neuropathic pain by inhibition of STAT1 phosphorization
Project/Area Number |
15K20047
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology
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Research Institution | Ehime University |
Principal Investigator |
|
Research Collaborator |
TANAKA Junya
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | マイクログリア活性化 / マイクログリア / 神経保護 |
Outline of Final Research Achievements |
We investigated the therapeutic effects of Chemical X to nerve injury and neuropathic pain. Chemical X didn't have significant effects to inhibition of STAT1 phosphorization in CCI rats. But PSD95, one of neuronal marker, was significantly increased and microglial activation was significantly suppressed in Chemical X administered group. In spinal cord, activated microglia was observed not only in posterior horn but also in anterior horn. Activated microglia with flattened shape intimately attached to large neurons in anterior horn, while those in the left posterior horn displayed amoeboid-like shape and the attachment to neurons was not apparent. We are continuously investigating therapeutic effects of Chemical X and focusing to the difference of activation of microglia in spinal cord.
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Report
(3 results)
Research Products
(1 results)
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[Journal Article] Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.2017
Author(s)
Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI.
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Journal Title
Brain, Behavior, and Immunity.
Volume: 60
Pages: 282-292
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant