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Elucidation of the mechanism of postoperative cognitive dysfunction through epigenetics

Research Project

Project/Area Number 15K20051
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionSapporo Medical University

Principal Investigator

Tachibana Shunsuke  札幌医科大学, 医学部, 研究員 (30737309)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords術後認知機能障害 / 手術ストレス / トランスクリプトーム解析 / デクスメデトミジン / 術後認知機能低下 / 麻酔手術ストレス / 海馬 / 術後認知機能 / セボフルラン
Outline of Final Research Achievements

We performed transcriptomic analysis and comprehensively analyzed the expression changes of messenger RNA (mRNA) in the brain, especially in the hippocampus due to surgery and anesthesia stress. Furthermore, we identified the all expression genes that increased or decreased by surgery and anesthesia stress, and also found that the expression of a specific gene changes in conjunction with the deterioration of cognitive function examined in the Burns Maze test.
In this study, we were able to elucidate a part of the mechanism of post oeprative cognitive dysfunction (POCD), and clarify the specify mRNA as a marker that could predict the onset of cognitive dysfunction.
And, we believe that the information provided from this research will bring significant meaning to future research.

Academic Significance and Societal Importance of the Research Achievements

術後認知機能障害の一つの機序を解明することができた。これらの結果から、予防法の確立も期待することができる。
実際の臨床現場においても、認知機能低下を予防するための戦略を立てることができ、医療費の削減につなげることができる。社会的意義は大変大きい。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2016 2015

All Journal Article (1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 麻酔科医として術後認知機能障害を俯瞰する2018

    • Author(s)
      立花俊祐
    • Journal Title

      臨床麻酔

      Volume: 7 Pages: 1003-9

    • Related Report
      2018 Annual Research Report
  • [Presentation] デクスメデトミジンは、高齢マウスにおいて手術侵襲由来のMapt発現増大を抑制し、術後の認知機能低下を減弱する。2019

    • Author(s)
      立花俊祐
    • Organizer
      第23回日本神経集中治療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dexmedetomidine attenuates up-regulation of the Rtn4rl2 gene and restores down-regulation of the Syt1 gene induced by sevoflurane/surgery stress in the hippocampus of elderly mice2018

    • Author(s)
      立花俊祐
    • Organizer
      The European anaesthesiology congress, Euroanaesthesia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dexmedetomidine attenuates up-regulation of the Rtn4rl2 gene and restores down-regulation of the Syt1 gene induced by sevoflurane/surgery stress in the hippocampus of elderly mice2018

    • Author(s)
      立花俊祐、山蔭道明
    • Organizer
      Euroanaesthesia 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] トランスクリプトーム解析を用いた術後認知機能障害の機序解明2016

    • Author(s)
      立花俊祐、早瀬知、山蔭道明
    • Organizer
      日本麻酔科学会第63回学術集会JAシンポジウム:Neuroscience up to date:postoperative cognitive dysfunction
    • Place of Presentation
      福岡
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Possible Mechanism of Neuroinflammation Induced by Surgical Procedure in the Mouse Hippocampus Determined by Using Transcriptome Analysis2015

    • Author(s)
      Shunsuke Tachibana
    • Organizer
      ASA annual meeting
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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