| Project/Area Number |
15K20152
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kumamoto University |
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Principal Investigator |
ITOH Fumiko 熊本大学, 医学部附属病院, 助教 (90648271)
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| Co-Investigator(Renkei-kenkyūsha) |
KATABUCHI Hidetaka 熊本大学, 大学院生命科学研究部産科婦人科学, 教授 (90224451)
HONDA Rituo 熊本大学, 大学院生命科学研究部産科婦人科学, 講師 (10301376)
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| Research Collaborator |
TUBOKI Junko 熊本大学, 医学部附属病院 地域医療・総合診療実践学寄付講座 (70772408)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 子宮内膜症 / 腹腔マクロファージ / 子宮内膜間質細胞 / 腹腔内環境 |
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| Outline of Final Research Achievements |
The results of the cytokine array showed up-regulated IL-1β, IL-2, IL-8, IP-10, MIP-1β, RANTES, TNF-α and sTREM-1 production in ascites of endometriosis patients. GM-CSF and GM-CSF receptor mRNAs were expressed on macrophages and ESCs, and GM-CSF significantly and dose-dependently induced ESCs proliferation. GM-CSF may be associated with interaction between ESCs and macrophages in development of endometriosis. Corosolic acid, a triterpenoid compound, inhibited ESC proliferation and Stat3 activation. Targeting Stat3 signals or the regulation of macrophage function may aid the treatment of patients with endometriosis.
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