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Involvement of transcription factor HOXD9 in the malignant phenotype of cervical cancer

Research Project

Project/Area Number 15K20159
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

SUGA Yukako  慶應義塾大学, 医学部(信濃町), 助教 (40459558)

Research Collaborator KAWAKMI Yutaka  慶應義塾大学, 医学部, 教授 (50161287)
IWATA Takashi  慶應義塾大学, 医学部, 講師 (30296652)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsHOXD9 / P97プロモーター / 子宮頸癌 / HPV陰性腺癌 / P53
Outline of Final Research Achievements

Expression changes of all genes by suppressing HOXD9 in cervical cancer cell lines SKG-3B were examined by DNA chip.Based on IPA analysis, P53 signaling was activated after suppression of HOXD9 expression in SKG-3B cells. P53 gene expression did not change, while the P53 protein level was elevated in HOXD9 supressed SKG3B and Siha cells. Luciferase activity was significantly decreased after HOXD9 expression was suppressed in SKG-IIIB cells. In the CHIP assay in SiHa cells (HPV16 positive), HOXD9 was shown to directry bind to the P97 promoter.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] 子宮頸癌における転写因子HOXD9の悪性形質への関与と分子生物学的機序の解明2017

    • Author(s)
      佐伯直彦、岩田卓、菅祐佳子、ほか
    • Organizer
      第59回日本婦人科腫瘍学会学術講演会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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