Elucidating a factor of the therapy resistance of HPV related oropharyngeal cancer by using comrehensive analysis

• Project/Area Number: 15K20202
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: Takemoto Norihiko 大阪大学, 医学系研究科, 助教 (20636485)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 中咽頭癌 / ヒトパピローマウイルス / 治療抵抗因子 / 放射線抵抗因子 / プロテオーム解析

Outline of Final Research Achievements

In order to investigate the factor of therapy resistance of HPV related oropharyngeal carcinoma(HPV-OPC), expression gene in HPV-OPC cell line with radioresistance and in patient with HPV-OPC derived xenograft model mouse were compared and analyzed using microarray. Although the AKT signal was intensified in common after tolerance for radiotherapy and mouse transplantation, the mTOR signal was not enhanced. It seemed that a therapeutic resistance factor could exist in the AKT signal.