| Project/Area Number |
15K20214
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Fukushima Medical University (2017)
Sapporo Medical University (2015-2016) |
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Principal Investigator |
Kawata Koji 福島県立医科大学, 医学部, 助教 (20374572)
|
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| Research Collaborator |
YAMASHITA Keiji
NAGAYA Tomonori
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 濾胞ヘルパーT細胞 / 腸内細菌叢 / 免疫老化 |
|---|
| Outline of Final Research Achievements |
In this study, we examined a relationship between numerical frequency of T follicular helper (Tfh) cells, which have an important role in specific humoral immunity, and structural change in intestinal microbiota. In the mice orally treated with antibiotics, the serum revels of IL-2, the cytokine inhibiting Tfh differentiation, were notably increased. It has been reported that a T cell population expressing Tfh-like phenotype were increased with age in normal mice. In our study, a significant increase of Tfh cells was observed in D-galactose-induced aging model mice, while antibiotics treatment effectively inhibited the increment of Tfh cells. These results suggested that intestinal microbiota might be involved in differentiation and numerical regulation of Tfh-like cells, which might contribute to immunosenescence, through a regulation of IL-2 production.
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