Regeneration of tracheal epithelium using induced pluripotent stem cells

• Project/Area Number: 15K20216
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Fukushima Medical University
• Principal Investigator: Ikeda Masakazu 福島県立医科大学, 医学部, 助手 (40707486)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: iPS細胞 / 気管上皮 / 再生医療

Outline of Final Research Achievements

The purpose of this study is shortening of the epithelialization period of inner side of artificial materials in the reconstruction of the trachea defect using the artificial materials. It was demonstrated that tracheal epithelium derived from induced pluripotent stem cells could survive without a becoming a tumor in nude rats in vivo.
Because a tracheal epithelium derived from induced pluripotent stem cells implanted it to artificial materials and an attendant, the possibility that we could realize shortening of the epithelialization period was demonstrated.

Research Products

• [Journal Article] Regeneration of tracheal epithelium using mouse induced pluripotent stem cells (2016)
  • Author(s): Ikeda M, Imaizumi M, Yoshie S, Otsuki K, Miyake M, Hazama A, Wada I, Omori K
  • Journal Title: Acta Otolaryngol Volume: Epub ahead of print Issue: 4 Pages: 1-6
  • DOI: 10.3109/00016489.2015.1121548
  • Peer Reviewed
• [Presentation] Regeneration of Mouse Induced Pluripotent Stem Cell for Regeneration of Tracheal Epithelial Cells (2015)
  • Author(s): 池田雅一
  • Organizer: 13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Place of Presentation: 東京
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] マウス iPS 細胞を用いた気管上皮組織の再生 (2015)
  • Author(s): 池田雅一
  • Organizer: 第67回気管食道科学会
  • Place of Presentation: 福島
  • Year and Date: 2015-11-20
• [Presentation] Differentiation of Mouse Induced Pluripotent Stem Cell for Regeneration of Tracheal Epithelial Cells (2015)
  • Author(s): 池田雅一
  • Organizer: The 136th Annual Meeting of the American Laryngological Association
  • Place of Presentation: ボストン
  • Year and Date: 2015-04-22
  • Int'l Joint Research