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Change of somatosensory function of the tongue caused by chorda tympani nerve disorder and activation of MAP kinase in Geniculate ganglion neurons after middle ear surgery

Research Project

Project/Area Number 15K20235
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionHyogo Medical University

Principal Investigator

KATSURA HIROKAZU  兵庫医科大学, 医学部, 講師 (90533761)

Research Collaborator MAEDA EMI  
TATUMI EMIKO  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords鼓索神経 / 三叉神経 / 舌知覚異常 / アブミ骨手術 / 舌知覚障害 / 中耳手術 / 味覚障害
Outline of Final Research Achievements

The CTN was gently touched or stretched in all patients. Postoperative thresholds on the operated side were significantly higher than preoperative thresholds in all tests in the patients who underwent all 3 kinds of tests. Tongue somatosensory symptoms improved significantly earlier than the taste disturbance postoperatively, and the sensory thresholds returned to the baseline along with recovery of symptoms. These findings suggest that dysfunction of the chorda tympani nerve (CTN) occurred following surgery even when the CTN was preserved, and that the sensory nerve threshold of the tongue correlated with the symptom of lingual numbness. The CTN may play a role not only in taste function, but also in the somatosensory function of the tongue.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Change of somatosensory function of the tongue caused by chorda tympani nerve disorder after stapes surgery.2017

    • Author(s)
      Maeda E, Katsura H, Nin T, Sakaguchi-Fukunaga A, Mishiro Y, Sakagami M.
    • Journal Title

      The Laryngoscope

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ラット鼓索神経切断モデルにおける膝神経節での分子生物学的変化と舌知覚鈍麻の関係について2016

    • Author(s)
      巽恵美子
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2016-05-18
    • Related Report
      2015 Research-status Report
  • [Presentation] アブミ骨手術後の舌知覚・味覚閾値変化と自覚症状の推移2015

    • Author(s)
      前田英美
    • Organizer
      日本耳科学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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