| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In this study, we examined how eosinophils are involved in pathogenesis of murine allergic rhinitis model.It is well known that in the late phase of allergic rhinitis, eosinophils accumulate in the nasal mucosa and play an important role in causing nasal obstruction. However, since eosinophils are multifunctional immune cells, it is considered that eosinophils may be involved in the pathology in various aspects other than the nasal mucosa. Therefore, the role of eosinophils was examined by comparing wild type mouse and eosinophil deficient mouse which induced allergic rhinitis model.
As a result, it was found that eosinophils may exacerbate the early phase and inhibit antigen-specific IgE production. Eosinophils in the nasal mucosa were also thought to affect the fractionation of the other immune cells.
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