Research Project
Grant-in-Aid for Young Scientists (B)
The PPARγ concentrations in the aqueous humor and vitreous fluid were significantly higher in PDR patients than in controls (P<0.0005). There was a significant positive correlation between the PPARγ and VEGF concentrations (P<0.0005). The level of PPARγ increased as the clinical stage advanced. The expressions of the mRNA and protein of PPARγ were higher in the membranes of PDR than those of controls. Anti-VEGF therapy significantly reduced the VEGF concentration (P<0.0001) but not the PPARγ concentration. PPARγ may play an important role and a therapeutic target in the pathogenesis of PDR.
All 2015
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Funded Workshop (1 results)
J Diabetes Complications
Volume: 29 Issue: 2 Pages: 275-281
10.1016/j.jdiacomp.2014.10.010