| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Cytomegalovirus (CMV) infection in healthy individuals is asymptomatic and results in latent infection, but it causes severe disease in infected fetuses and premature infants or in immunocompromised patients. Thus, we studied CMV-specific immune response and mechanism of homeostatic maintenance using the infection model of retinal pigment epithelial cells or hematopoietic stem cells which are infection targets of CMV. This study suggest that CMV-infected retinal pigment epithelial cells migrate T cells to eliminate infected cells and induce inflammatory reactions, while maintaining homeostasis by inducing differentiation of regulatory T cells and suppressing inflammatory reactions.
|
