Study on CMV antigen-specific immune response and homeostatic maintenance of retinal pigmented epithelial cells using iPS cells
| Project/Area Number |
15K20271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | サイトメガロウイルス / 網膜色素上皮細胞 / 恒常性 / 造血幹細胞 / 潜伏感染 / 眼の恒常性 / iPS細胞 / HLA |
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| Outline of Final Research Achievements |
Cytomegalovirus (CMV) infection in healthy individuals is asymptomatic and results in latent infection, but it causes severe disease in infected fetuses and premature infants or in immunocompromised patients. Thus, we studied CMV-specific immune response and mechanism of homeostatic maintenance using the infection model of retinal pigment epithelial cells or hematopoietic stem cells which are infection targets of CMV. This study suggest that CMV-infected retinal pigment epithelial cells migrate T cells to eliminate infected cells and induce inflammatory reactions, while maintaining homeostasis by inducing differentiation of regulatory T cells and suppressing inflammatory reactions.
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Report
(4 results)
Research Products
(4 results)
