| Project/Area Number |
15K20283
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 網膜 / 加齢黄斑変性 / 抗酸化酵素 / タイトジャンクション / ルテイン / 網膜色素上皮 |
|---|
| Outline of Final Research Achievements |
Photo-induced disruption of tight junction in the retinal pigment epithelium was recovered only slowly. However, lutein administration reduced tissue ROS levels and promoted the recovery. Lutein prolonged photo-induced mRNAs of antioxydative enzymes, SOD1 and SOD2, and SOD activity. Tissue mRNA levels of a photo-induced inflammatory cytokine, MCP-1, was suppressed by lutein. Similar effect was observed in ARPE19 cell line. Lutein promoted recovery of disrupted tight junction reducing oxidative stress most likely by both scavenging ROS and inducing antioxydative enzymes.
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