Examination of PPAR alpha dependent mechanism for diabetic retinopathy
| Project/Area Number |
15K20291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
shiono akira 聖マリアンナ医科大学, 医学部, 助教 (20737598)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | PPARα / トロンボモジュリン / 糖尿病網膜症 |
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| Outline of Final Research Achievements |
Genome-wide analysis using microarray and Chip-sequence showed that the PPARα activation suppresses the inflammatory genes expression, and increases thrombomodulin expression in vascular endothelial cells. And we showed that thrombomodulin is PPARα directed target gene by Chip-sequence. In vivo study, PPARα ligands suppressed inflammatory genes expression in retina and monocyte adhesion in retinal vessels thrombomodulin dependent manner in streptozotocin induced diabetes mellitus rat. These results suggested the anti-inflammatory effect of PPARα activation through the thrombomodulin expression in retina.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis2015
Author(s)
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] HistoneH2B, a potential role of cell death ligand, induced RGC death through Toll like receptor 4 in the vitreous of acute angle closure2016
Author(s)
Munemasa Y,Kitaoka Y, Sase K,Kojima K,Shiono A, Kogo J, Tokuda N, Takagi H
Organizer
2016 annual meeting of The Association for Research in Vision and Ophthalmology
Place of Presentation
Seattle,USA
Related Report
Int'l Joint Research
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