Involvement of oral bacterial invasion and antibacterial peptides in oral ulcerative mucositis-induced pain
| Project/Area Number |
15K20377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Hitomi Suzuro 九州歯科大学, 歯学部, 助教 (70548924)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 口内炎 / 口腔内細菌 / 抗菌物質 / 疼痛 / 感染性炎症 / 抗菌ペプチド / 細菌感染 / 自発痛 / 機械的アロディニア / 三叉神経節 / Hamp / Seｒpina3n |
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| Outline of Final Research Achievements |
Oral ulcerative mucositis induces severe pain. However, the pain mechanisms are not well known. To reveal whether oral bacteria invaded from the ulcer region are involved in the oral ulcerative mucositis-induced pain, we evaluated the pain-related behavior and gene expression level using oral ulcerative mucositis model rats. Spontaneous and mechanical pain are observed in the model and an antibacterial drug inhibited the pain. An antibacterial peptide mRNA in trigeminal ganglion and the ulcer region were upregulated in the model. These results suggested that oral ulcerative mucositis-induced pain is caused by bacterial invasion into the mucosal tissue and antibacterial peptides are released from ganglion cells and ulcer region.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels.2017
Author(s)
Hitomi, S., Ono, K., Terawaki, K., Matsumoto, C., Mizuno, K., Yamaguchi, K., Imai, R., Omiya, Y., Hattori, T., Kase, Y., Inenaga, K.
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Journal Title
Pharmacological Research
Volume: 117
Pages: 288-302
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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