Research Project
Grant-in-Aid for Young Scientists (B)
Oral ulcerative mucositis induces severe pain. However, the pain mechanisms are not well known. To reveal whether oral bacteria invaded from the ulcer region are involved in the oral ulcerative mucositis-induced pain, we evaluated the pain-related behavior and gene expression level using oral ulcerative mucositis model rats. Spontaneous and mechanical pain are observed in the model and an antibacterial drug inhibited the pain. An antibacterial peptide mRNA in trigeminal ganglion and the ulcer region were upregulated in the model. These results suggested that oral ulcerative mucositis-induced pain is caused by bacterial invasion into the mucosal tissue and antibacterial peptides are released from ganglion cells and ulcer region.
All 2017 2016 2015
All Journal Article (3 results) (of which Peer Reviewed: 2 results, Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 3 results)
Pharmacological Research
Volume: 117 Pages: 288-302
10.1016/j.phrs.2016.12.026
Arch Oral Biol
Volume: 66 Pages: 30-37
10.1016/j.archoralbio.2016.02.002
日本歯科評論
Volume: 75 Pages: 129-135
