Nobel surface treatment for better implant-ECM interface

• Project/Area Number: 15K20445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kyushu University
• Principal Investigator: Furuhashi Akihiro 九州大学, 大学病院, 医員 (60608975)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 細胞外マトリックス / 細胞外基質 / 歯科インプラント

Outline of Final Research Achievements

The cell adhesion is divided into two types; cell-cell contact and cell-extracellular matrix (ECM) contact. Dental implants are one of the ECM environments for the surrounding cells. In this study, cell-cell contact and cell-ECM contact are evaluated. Cells were seeded onto various kinds of coated dishes. And 3 dimensional (3D) cultures were also performed. Cells showed different adhesion pattern onto various coating. When cultured in 3-D condition, the cells showed 3-D branching-like morphology.

Research Products

• [Int'l Joint Research] ペンシルバニア大学(米国)
• [Journal Article] Soft tissue sealing around dental implants based on histological interpretation (2016)
  • Author(s): Atsuta I, Ayukawa Y, Kondo R, Matsuura Y, Ohshiro W, Furuhashi A, Tsukiyama Y, Koyano K.
  • Journal Title: Journal of Prosthodontic Research Volume: 60 Issue: 1 Pages: 3-11
  • DOI: 10.1016/j.jpor.2015.07.001
  • NAID: 130007936706
  • ISSN: 1883-1958, 1883-9207
  • Year and Date: 2016-01-25
  • Peer Reviewed
• [Journal Article] Neural Progenitor-Like Cells Induced From Human Gingiva-Derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration (2016)
  • Author(s): Zhang Q, Nguyen P, Xu Q, Park W, Lee S, Furuhashi A, Le A
  • Journal Title: stem cell translational medicine Volume: 5 Issue: 2 Pages: 1-13
  • DOI: 10.5966/sctm.2016-0177
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of CaCl2 hydrothermal treatment of titanium implant surfaces on early epithelial sealing (2015)
  • Author(s): Oshiro W. Ayukawa Y, Atsuta I, Furuhashi A, Yamazoe J, Kondo R, Sakaguchi M, Matsuura Y, Tsukiyama Y, Koyano K.
  • Journal Title: Colloids and Surfaces B Biointerphases Volume: 未定 Pages: 141-147
  • DOI: 10.1016/j.colsurfb.2015.04.025
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Acceleration of hard and soft tissue healing in the oral cavity by a single transmucosal injection of fluvastatin-impregnated poly (lactic-co-glycolic acid) microspheres. An in vitro and rodent in vivo study (2015)
  • Author(s): Yasunami N, Ayukawa Y, Furuhashi A, Atsuta I, Rakhmatia YD, Moriyama Y, Masuzaki T, Koyano K
  • Journal Title: Biomed Mater Volume: 11 Issue: 1 Pages: 015011-015011
  • DOI: 10.1088/1748-6041/11/1/015001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fibroblast attachment onto novel titanium mesh membranes for guided bone regeneration (2014)
  • Author(s): Rakhmatia YD, Ayukawa Y, Atsuta I, Furuhashi A, Koyano K
  • Journal Title: Odontology Volume: - Issue: 2 Pages: 2180226-2180226
  • DOI: 10.1007/s10266-014-0151-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Effect of Ca-HT Treatment of Titanium on Adhesion Properties (2017)
  • Author(s): Takuya Haraguchi, Yasunori Ayukawa, Akihiro Furuhashi, Ikiru Atsuta, Yoichiro Ogino, Wakana Oshiro, Noriyuki Yasunami, Kiyoshi Koyano
  • Organizer: 95th General Session of the International Association for Dental Research
  • Place of Presentation: Moscone Center, CA
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] INDUCED NEURAL PROGENITOR-LIKE CELLS FROM HUMAN GINGIVA-DERIVED MESENCHYMAL STEM CELLS REGULATE MYELINATION OF SCHWANN CELLS IN RAT SCIATIC NERVE REGENERATION (2017)
  • Author(s): Zhang Q, Nguyen P, Xu Q, Park W, Lee S, Furuhashi A, Le A
  • Organizer: American Cleft Palate-Craniofacial association 74th annual meeting
  • Place of Presentation: Broadmoor in Colorado Springs, CO
  • Year and Date: 2017-03-13
  • Int'l Joint Research
• [Presentation] チタンの塩化カルシウム水熱処理がタンパク質，細胞および細菌の付着に与える影響 (2016)
  • Author(s): 原口拓也,鮎川保則,荻野洋一郎,熱田生,安波礼之,古橋明大,大城和可奈,古谷野潔
  • Organizer: 第46回公益社法人日本口腔インプラント学会学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2016-09-16
• [Presentation] ジルコニア製インプラントにおける軟組織封鎖性の検討 (2016)
  • Author(s): 熱田生,鮎川保則,古橋明大,成松生枝,古谷野潔
  • Organizer: 日本歯科理工学会九州地方会夏期セミナー
  • Place of Presentation: 北九州市
  • Year and Date: 2016-08-18
• [Presentation] Potential Application of Human Adult Stem Cells from the Dental Follicle Tissues for Salivary Gland Regeneration (2016)
  • Author(s): Xu Q#, Furuhashi A#, Zhang Q, Jiang C, Le A.※. # Both authors contribute equally to this study
  • Organizer: Penn Dental Medicine Research Day
  • Place of Presentation: University of Pennsylvania, PA
  • Int'l Joint Research
• [Presentation] PLGA-フルバスタチン複合体局所単回投与による抜歯窩及びインプラント周囲組織に対する治癒促進効果の検討 (2015)
  • Author(s): 安波礼之, 鮎川保則, 古橋明大, 熱田生, 古谷野潔
  • Organizer: 第45回公益社団法人日本口腔インプラント学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2015-09-21