The development of new methods of bone regeneration using honeycomb collagen induced early vessel formation

• Project/Area Number: 15K20468
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Hokkaido University
• Principal Investigator: yuge fumihiko 北海道大学, 大学病院, 医員 (60713609)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ハニカムコラーゲン / 骨再生 / 骨造成

Outline of Final Research Achievements

The pore structure of biomaterials induces early Vessel formation and granulation tissue formation. and blood Vessels are necessary for bone regeneration.The purpose of this study is to explore honeycomb collagen with tunnel structure will have efficacy for born formation.The tunnel direction of the honeycomb collagen was implanted parallel or perpendicularly to Maxillary alveolar bone of beagles.The dogs were sacrificed 8 weeks post-surgery, and healing was evaluated histologically.Maxillary alveolar bone of beagles of 2D slice images was acquired by a CT and a 3D image date set was prepared by combing these images.