| Project/Area Number |
15K20495
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
TSUDA Susumu 大阪歯科大学, 歯学部, 助教 (50581021)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ポリロタキサン / シクロデキストリン / 生体吸収性材料 / 生分解性高分子 |
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| Outline of Final Research Achievements |
The polyrotaxanes for organic-inorganic hybrid materials were formed from cyclodextrins (as macrocyclic compounds) and bioabsorbable polymers (as backbone strings), such as polylactic acid (PLC), polyglycol acid (PGA) and polycaprolactone (PCL), by a standard wetting method in aqueous mixed solvents. The formations of polyrotaxanes were confirmed by NMR measurements, MALDI-TOF MS spectroscopy, HPLC analysis and element analysis. Next, The crosslinkable connecting units were introduced in the macrocyclic parts composed of the polylotaxane for development of organic-inorganic hybrid materials having moderate strength. The new cyclodextrin derivatives bearing imidazolium salts or cyclopentadiene were synthesized and it is confirmed that the CD derivatives acted as crosslinking units.
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