Elucidation of oral cancer carcinogenesis mechanism from a microRNA perspective
| Project/Area Number |
15K20501
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | microRNA / 口腔がん / 発癌 / 癌化 / miRNA / 白板症 / p62 |
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| Outline of Final Research Achievements |
In this study, I investigated whether leukoplakia can be distinguished by miRNA expression levels. microRNA microarray profiling was used to compare microRNA expression in 5 formalin-fixed, paraffin-embedded (FFPE) leukoplakia resected specimen. Some microRNAs exhibited statistically significant differences in expression between the leukoplakia, normal oral mucosal epithelium and oral cancer samples. microRNA expression profiles in leukoplakia may potentially be used to identify oral cancer carcinogenesis mechanism, and microRNAs that are up-regulated in leukoplakia may be targets for therapeutic intervention.
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Report
(3 results)
Research Products
(2 results)
