Elucidation of oral cancer carcinogenesis mechanism from a microRNA perspective

Research Project

Project/Area Number	15K20501
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	University of Tsukuba
Principal Investigator	UCHIDA Fumihiko 筑波大学, 附属病院, 医員 (70736008)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	microRNA / 口腔がん / 発癌 / 癌化 / miRNA / 白板症 / p62
Outline of Final Research Achievements	In this study, I investigated whether leukoplakia can be distinguished by miRNA expression levels. microRNA microarray profiling was used to compare microRNA expression in 5 formalin-fixed, paraffin-embedded (FFPE) leukoplakia resected specimen. Some microRNAs exhibited statistically significant differences in expression between the leukoplakia, normal oral mucosal epithelium and oral cancer samples. microRNA expression profiles in leukoplakia may potentially be used to identify oral cancer carcinogenesis mechanism, and microRNAs that are up-regulated in leukoplakia may be targets for therapeutic intervention.

Report

(3 results)