Analysis of characteristics of lymphatic microcirculation within metastatic lymph nodes focusing on endothelial cell junctional complex

Research Project

Project/Area Number	15K20522
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Kobe University
Principal Investigator	Akashi Masaya 神戸大学, 医学研究科, 講師 (40597168)
Project Period (FY)	2015-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	口腔癌 / リンパ管 / 放射線治療 / リンパ節転移 / 悪性腫瘍 / リンパ節 / 細胞接着
Outline of Final Research Achievements	The effects of radiation on morphology, cell integrity, and permeability of lymphatic endothelial cells were analyzed for a better understanding of relationship between cancer and lymphatic vessels. As a result, changes in lymphatic endothelium were found under the influence of radiation, which could contribute to an understanding of the onset mechanism of complications such as lymph node metastasis of cancer and lymphedema after radiation.
Academic Significance and Societal Importance of the Research Achievements	本研究によりリンパ浮腫発症因子や増悪因子がリンパ管内皮細胞間接着に対しどのような構造的変化を及ぼすかが解明され、さらに、この構造的変化をリバースさせ得る薬剤を網羅的に検討することで、今後リンパ浮腫の根治療法確立に向け大きく前進することが期待される。