| Project/Area Number |
15K20560
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
Noguchi Sunk 東京歯科大学, 歯学部, 非常勤講師 (30615406)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔癌 / 細胞診 / 免疫染色 / 液状化検体細胞診 / 舌扁平上皮癌 / OSCC / 癌化関連タンパク / 口腔がん / スクリーニング / フィールドキャンサライゼーション / 上皮異形成 |
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| Outline of Final Research Achievements |
Purpose of this study, we aimed to improve the diagnostic accuracy in cytodiagnosis by combining retrieval of carcinogenesis-associated protein expression in oral cytology. We examined that how dose carcinogenesis-associated proteins expression, used laser capture microdissection and PCR methods. And we tried mapping of carcinogenesis-associated proteins on cancer specimens. As a result, we certified that the expression of these carcinogenesis-associated proteins gradient increases mainly in tumors. Based on this fact, we inspected expression of these carcinogenesis-associated proteins on early tongue cancer. Aim to confirmation of Liquid-based Oral Cytology.As a result, it is suggested that accuracy of Liquid-based Oral Cytodiagnosis will improve by using the immunohistological staining, and possibility of early detect of the oral cancer.
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