Development of new diagnostic and of cognitive dysfunction using saliva by metabolome analysis
| Project/Area Number |
15K20566
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
To Masahiro 神奈川歯科大学, 大学院歯学研究科, 助教 (70707348)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 唾液 / 認知症 / メタボローム / メタボローム解析 |
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| Outline of Final Research Achievements |
In this study, to clarify the relationship between the pathology of cognitive dysfunction and the change of saliva components in dementia patients, we aimed to develop a new diagnostic and evaluation method of cognitive dysfunction using saliva by metabolome analysis. We conducted experiments on animals and human subjects, and revealed the changes in saliva components by cognitive dysfunction using metabolome analysis. These findings indicate relation to saliva component and cognitive function, and it was possible to study of saliva test.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Salivary lactoferrin is transferred into the brain via the sublingual route.2017
Author(s)
Hayashi T, To M, Saruta J, Sato C, Yamamoto Y, Kondo Y, Shimizu T, Kamata Y, Tsukinoki K
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Journal Title
Bioscience, Biotechnology, Biochemistry
Volume: 29
Issue: 7
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Grinding patterns in migraine patients with sleep bruxism: a case-controlled study.2016
Author(s)
Kato M, Saruta J, Takeuchi M, Sugimoto M, Kamata Y, Shimizu T, To M, Fuchida S, Igarashi H, Kawata T, Tsukinoki K.
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Journal Title
CRANIO®: The Journal of Craniomandibular & Sleep Practice
Volume: 23
Pages: 1-7
Related Report
Peer Reviewed / Open Access
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