Morecular pathology involved in phenotypic expression and morphological chenges in jaw lesions

• Project/Area Number: 15K20571
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: Ochiai Takanaga 松本歯科大学, 歯学部, 講師 (20410417)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 分子病理学 / 形質変化 / 腫瘍病理学 / 形態形成 / 形質発現 / 臨床腫瘍学 / 顎骨部病変

Outline of Final Research Achievements

Odontogenic lesions appear some kinds of abnormal morphologic chenges such as squamous metaplasia and abnormal keratinization. Cornified envelope (CE) is an important structure for keratinization. Ameloblastoma expressed involucrin (IVL), small proline rich protein (SPR) and transglutaminase1 (TG1). In odontogenic keratocyst, TG3 and TG5 crosslinked by IVL. TG1 and TG3 were accociated with IVL in calcifing odontogenic cyst. These results suggested the possibility of keratinization mechanism of each odontogenic lesions.

Research Products

• [Presentation] Regulation factors of morphological changes in odontogenic tumor. (2017)
  • Author(s): 落合隆永
  • Organizer: 第59回歯科基礎医学会
• [Presentation] 歯原性角化嚢胞における角化関連因子の局在 (2017)
  • Author(s): 落合隆永、嶋田勝光、長谷川博雅
  • Organizer: 第60回口腔科学会中部地方部会
• [Presentation] Transglutaminaseの口腔粘膜上皮における局在 (2017)
  • Author(s): 嶋田勝光、落合隆永、長谷川博雅
  • Organizer: 第60回口腔科学会中部地方部会
• [Presentation] 口腔粘膜上皮における Small proline rich proteins の局在 (2017)
  • Author(s): 嶋田勝光、落合隆永、長谷川博雅
  • Organizer: 第10回日本口腔検査学会
• [Presentation] 口腔粘膜上皮の周辺帯関連タンパク質の局在-TransglutaminaseとSmall prorin-rich proteins (2017)
  • Author(s): 嶋田勝光、落合隆永、長谷川博雅
  • Organizer: 第85回松本歯科大学学会
• [Presentation] Cornified cell envelope related proteins in odontogenic tumors (2016)
  • Author(s): Takanaga Ochiai, Katsumitsu Shimada and Hiromasa Hasegawa
  • Organizer: 13th Biennal congress of the European association of oral medicine
  • Place of Presentation: Turin (Italy)
  • Year and Date: 2016-09-15
  • Int'l Joint Research
• [Presentation] Small proline-rich proteins in keratocystic odontogenic tumor. (2016)
  • Author(s): Katsumitsu Shimada, Takanaga Ochiai and Hiromasa Hasegawa
  • Organizer: 13th Biennal congress of the European association of oral medicine
  • Place of Presentation: Turin (Italy)
  • Year and Date: 2016-09-15
  • Int'l Joint Research
• [Presentation] 角化嚢胞性歯原性腫瘍の角化機序 (2016)
  • Author(s): 落合隆永，中野敬介，長谷川博雅
  • Organizer: 第58回歯科基礎医学会
  • Place of Presentation: 札幌コンベンションセンター（北海道）
  • Year and Date: 2016-08-26
• [Presentation] Cornified cell envelope related proteins in ghost cells (2016)
  • Author(s): Takanaga Ochiai, Katsumitsu Shimada and Hiromasa Hasegawa
  • Organizer: 第27回日本臨床口腔病理学会
  • Place of Presentation: 広島大学 広仁会館（広島県）
  • Year and Date: 2016-08-12
• [Presentation] Immunohistochemical analysis of cornified cell envelope related proteins in keratocystic odontogenic tumor. (2015)
  • Author(s): 落合隆永、中野敬介、長谷川博雅
  • Organizer: 第57回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市）
  • Year and Date: 2015-09-13
• [Presentation] 歯原性の幽霊細胞における角化関連因子の免疫組織学的検討 (2015)
  • Author(s): 落合隆永、嶋田勝光、中野敬介、長谷川博雅
  • Organizer: 第26回日本臨床口腔病理学会総会・学術大会
  • Place of Presentation: 北海道大学学術交流会館（北海道札幌市）
  • Year and Date: 2015-07-31