| Project/Area Number |
15K20587
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Itoh Shinsuke 大阪大学, 歯学研究科, 助教 (40633706)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Runs/Cbfb / 神経堤細胞 / 頭頚部発生 / 鎖骨頭蓋異形成症 / 頭蓋冠形成 / 口蓋裂 / 小下顎 / Runx/Cbfb / 頭蓋顔面発生 / 頭蓋骨形成 |
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| Outline of Final Research Achievements |
In this study, we analyzed the functional role of Runx/Cbfb in the craniofacial formation, using conditional knockout (cKO) mice in which Cbfb gene was inactiveated in cranial neural crest cells specifically (Wnt1Cre; Cbfbfl/fl). We found that cKO mice exhibited delayed ossification in carvalia and midfacial region around nose, cleft palate and mandibular micrognathia. These results suggest that Runx/Cbfb signaling in neural crest cells is involved in the craniofacial abnormality with cleidocranial dysplasia.
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