| Project/Area Number |
15K20589
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯牙移動 / 疼痛発現メカニズム / TRPチャネル / 矯正歯科治療 / 疼痛メカニズム |
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| Outline of Final Research Achievements |
In the present study, we investigated if the new pain mechanism with Transient Receptor Potential (TRP) channel exist at experimental orthodontic tooth movement. There were TRPV2, TRPC1 and C6 in the periodontal ligament (PDL) tissues compared with the pulp tissues. The TRPV2-positive free nerve endings were observed in the PDL. Moreover, c-fos-positive cell were decreased at trigeminal subnucleus caudalis by the antagonist to the TRPV2. From the above, it is suggested that TRPV2 channel is concerned in the pain stimulus reception at orthodontic tooth movement.
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