| Project/Area Number |
15K20625
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
|
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| Research Collaborator |
Nakashima Keisuke
Usui Michihiko
Morishita Masaki
Nakamichi Ikuo
Muraoka Kousuke
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | apelin / GCF / adipokine / cytokine / aeplin / 歯周病 / 肥満 |
|---|
| Outline of Final Research Achievements |
In serum, apelin level were lower in periodontitis group and obesity/periodontitis group than in non-periodontitis group. In gingival crevicular fluid (GCF), apelin level were lower in obesity group and obesity/periodontitis group than non-periodontitis group. Furthermore, pretreatment with apelin decreased Porphyromonas gingivalis LPS-induced expression of inflammatory cytokines in J774.1 cells.
These observations suggest that reduction of apelin level of GCF in obesity patients aggravates periodontitis.
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