The analysis of pathogenic CD4+ T cells in mice model of Sjogren's syndrome

Research Project

Project/Area Number	15K20882
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Collagenous pathology/Allergology Pathobiological dentistry/Dental radiology
Research Institution	Keio University (2016) University of Tsukuba (2015)
Principal Investigator	Iizuka Mana 慶應義塾大学, 医学部(信濃町), 特任助教 (80734821)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	自己免疫疾患 / シェーグレン症候群 / T細胞 / CD4+ T細胞 / RORγt
Outline of Final Research Achievements	To reveal the pathological role of CD4+ T cells, we used RORγt Tg mice, which have been found to spontaneously develop severe sialadenitis-like Sjogren's syndrome (SS). Our results demonstrated that both RORγt-overexpressed CD4+ T cells and reduced Treg cells via suppression of IL-2 induced phosphorylation of STAT5 might contribute to the development of SS-like sialadeitis. This research was reported by the journal of "The Journal of Immunology".

Report

(3 results)