| Project/Area Number |
15K20928
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Epstein-Barr virus / 胃癌 / 癌幹細胞 |
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| Outline of Final Research Achievements |
To explore the cancer stem cells in EBV-associated gastric carcinoma, tissue microarrays were constructed using hundreds of surgically resected gastric cancer tissues. With these microarrays, we investigated the expressions of several stem cell markers, especially markers which reflect primitive/fetal phenotype, by immunohistochemistry. The results identified three different groups based on the expression patterns of these primitive/fetal markers. Among them, a group with frequent expression of primitive/fetal markers was found to behave aggressively, while the expression of these markers were infrequent in EBV-associated gastric carcinoma. These results demonstrated that these primitive/fetal markers were less likely to be associated with cancer stemness in EBV-associated gastric carcinoma.
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